Reaction profile

The FDA adverse-event record for labeled drug-species interaction

303 FDA adverse-event reports reference labeled drug-species interaction (VeDDRA 99963). See the species, breeds, and drugs most associated with it below.

303
reports citing this reaction
13.2%
death-coded share
Dog
most-affected species
Ivermectin
most-associated drug
Verify with FDA CVM →
303
Total Reports
40
Deaths
13.2%
Death Rate

Species Most Affected

Dog 150
Cat 139
Human 8
Horse 4
Goat 1
Lizard 1

Breeds Most Affected

Domestic Shorthair 89
Cat (unknown) 25
Retriever - Labrador 16
Dog (unknown) 13
Shepherd Dog - Australian 10
Unknown 10
Pit Bull 9
Chihuahua 8
Crossbred Canine/dog 8
Shepherd Dog - German 6

Associated Drugs

Ivermectin 71
Meloxicam 62
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 43
Ivermectin 10 Mg/Ml Solution For Injection 32
Ivermectin + Pyrantel As Pamoate Salt 18
Imidacloprid + Moxidectin 12
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 11
Carprofen 8
Florfenicol, Terbinafine, Betamethasone Acetate 8
Ivermectin 1.87% Paste 6
Ivermectin 1% Injection 5
Ivermectin(1%)/Clorsulon(10%) Injection 5
Nitenpyram 5
Melarsomine Dihydrochloride Injection 5
Gabapentin 5
Frunevetmab 5
Cefovecin Sodium 4
Moxidectin 4
Melarsomine Dihydrochloride 4
Doramectin 4

Labeled drug-species interaction Reaction Insights

303 reports name Labeled drug-species interaction; 40 recorded a death outcome (13.2% of reported events, not a population-level mortality rate). VeDDRA code: 99963.

By species: Dog (150 reports), Cat (139 reports), Human (8 reports). By breed: Domestic Shorthair (89), Cat (unknown) (25), Retriever - Labrador (16).

Most co-reported drugs: Ivermectin (71 reports), Meloxicam (62 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (43 reports), Ivermectin 10 Mg/Ml Solution For Injection (32 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.