Reaction profile

The FDA adverse-event record for labeled drug-species interaction

Name: Labeled drug-species interaction - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

310 FDA adverse-event reports reference labeled drug-species interaction (VeDDRA 99963). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#855 of 2,481
by report volume (all reactions): 310
reports citing this reaction: 13.2%
death-coded share: Dog
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Labeled drug-species interaction has 310 reports now versus 305 in that prior snapshot: 5 more (1.6%).

Report change: +5
Death-coded reports: +0
Death-coded share: −0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Labeled drug-species interaction changes

FDA AER · VeDDRA plate

Code 99963 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-LOW 310 reports
DEATH-ELEV 13.2%
MID-PACK #855/2481
PHOTO-FINISH Cloudy eye (for Miosi…
SPECIES-DOG Dog · 150
DRUG-LEAD Ivermectin · 71
DESK-WIDE 20 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Cloudy eye (for Miosis, Mydriasis, Anisocoria, Nystagmus - see 'Neurological') (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Labeled drug-species interaction

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

FDA AER report volume · neighbourhood around Labeled drug-species interaction

What the FDA AER plate says about Labeled drug-species interaction

Signature read: 41 death-coded reports is a heavy tail count for Labeled drug-species interaction in the CVM extract. Report volume sits in the middle third of the reaction corpus. 41 of 310 reports were death-coded (13.2% of named reports, not a population mortality rate). Nearest volume peer: Cloudy eye (for Miosis, Mydriasis, Anisocoria, Nystagmus - see 'Neurological') (±0 reports). Lead species Dog (150). Lead co-reported drug Ivermectin (71).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 150

Cat 146

Human 8

Horse 4

Goat 1

Lizard 1

Breeds Most Affected

Domestic Shorthair 96

Cat (unknown) 25

Retriever - Labrador 16

Dog (unknown) 13

Unknown 10

Shepherd Dog - Australian 10

Pit Bull 9

Chihuahua 8

Crossbred Canine/dog 8

Shepherd Dog - German 6

Associated Drugs

Ivermectin 71

Meloxicam 63

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 46

Ivermectin 10 Mg/Ml Solution For Injection 32

Ivermectin + Pyrantel As Pamoate Salt 18

Imidacloprid + Moxidectin 12

Ivermectin(1.55%)/Praziquantel(7.75%) Paste 11

Carprofen 8

Florfenicol, Terbinafine, Betamethasone Acetate 8

Ivermectin 1.87% Paste 6

Gabapentin 6

Frunevetmab 6

Ivermectin 1% Injection 5

Ivermectin(1%)/Clorsulon(10%) Injection 5

Nitenpyram 5

Melarsomine Dihydrochloride Injection 5

Cefovecin Sodium 4

Moxidectin 4

Melarsomine Dihydrochloride 4

Doramectin 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Labeled drug-species interaction, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (310 here).

Cloudy eye (for Miosis, Mydriasis, Anisocoria, Nystagmus - see 'Neurological') 310 Cushings disease NOS 310 Lack of efficacy (virus) - parvovirus (including feline panleukopenia) 310 Elevated haematocrit 311

Similar death-coded share

Nearest other reactions by death-coded share (13.2% here), distinct from the volume row.

Circling - behavioural disorder (see also Neurological disorders) 13.2% Lens opacity 13.2% Joint stiffness 13.2% Stranguria 13.3%

What to do with this reaction

Compare Labeled drug-species interaction's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Labeled drug-species interaction (#855 of 2,481 by report volume); death-coded 13.2%. PlainBreed reaction plate · death-coded report count stamp 41 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →