Reaction profile

The FDA adverse-event record for circling - behavioural disorder (see also 'neurological disorders')

165 FDA adverse-event reports reference circling - behavioural disorder (see also 'neurological disorders') (VeDDRA 2611). See the species, breeds, and drugs most associated with it below.

165
reports citing this reaction
9.7%
death-coded share
Dog
most-affected species
Sarolaner
most-associated drug
Verify with FDA CVM →
165
Total Reports
16
Deaths
9.7%
Death Rate

Species Most Affected

Dog 134
Cat 22
Horse 8
Cattle 1

Breeds Most Affected

Domestic Shorthair 17
Chihuahua 16
Crossbred Canine/dog 13
Retriever - Labrador 7
Terrier (unspecified) 6
Dog (unknown) 6
Terrier - Yorkshire 5
Terrier - Jack Russell 4
Pug 4
Terrier - Boston 4

Associated Drugs

Sarolaner 15
Pyrantel Pamoate;Sarolaner 15
Afoxolaner 13
Fluralaner Spot-On Solution 12
Fluralaner Chew Tablets 11
Selamectin 8
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 8
Fluralaner 13.64% 12-Week Chew 8
Milbemycin Oxime + Spinosad 7
Imidacloprid + Moxidectin 6
Buprenorphine 6
Moxidectin 5
Trilostane 5
Milbemycin Oxime + Praziquantel 5
Carprofen 4
Canine Parvovirus Strain Nl-35-D, P.35-D, 8-2-80;Canine Parainfluenza Virus, Str 4
Maropitant Citrate 4
Prednisone 4
Nitenpyram 4
Lotilaner 4

Circling - behavioural disorder (see also 'Neurological disorders') Reaction Insights

165 reports name Circling - behavioural disorder (see also 'Neurological disorders'); 16 recorded a death outcome (9.7% of reported events, not a population-level mortality rate). VeDDRA code: 2611.

By species: Dog (134 reports), Cat (22 reports), Horse (8 reports). By breed: Domestic Shorthair (17), Chihuahua (16), Crossbred Canine/dog (13).

Most co-reported drugs: Sarolaner (15 reports), Pyrantel Pamoate;Sarolaner (15 reports), Afoxolaner (13 reports), Fluralaner Spot-On Solution (12 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.