Reaction profile

The FDA adverse-event record for fluid in thorax

171 FDA adverse-event reports reference fluid in thorax (VeDDRA 1183). See the species, breeds, and drugs most associated with it below.

171
reports citing this reaction
66.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
171
Total Reports
113
Deaths
66.1%
Death Rate

Species Most Affected

Dog 118
Cat 38
Cattle 13
Rabbit 1
Pig 1

Breeds Most Affected

Domestic Shorthair 25
Retriever - Labrador 11
Chihuahua 7
Retriever - Golden 7
Shepherd Dog - German 6
Shepherd Dog - Australian 5
Domestic Longhair 5
Holstein-Friesian also known as Holstein 4
Aberdeen Angus 4
Terrier - Yorkshire 4

Associated Drugs

Milbemycin Oxime + Spinosad 19
Furosemide 17
Carprofen 13
Prednisone 13
Cefovecin 13
Moxidectin 12
Afoxolaner 11
Spinosad 10
Trilostane 10
Oclacitinib Maleate 9
Maropitant Citrate 9
Gabapentin 8
Antibiotic 8
Monensin Sodium 7
Doxycycline 7
Imidacloprid + Moxidectin 6
Pimobendan 6
Famotidine 6
Dexamethasone 5
Metronidazole 5

Fluid in thorax Reaction Insights

171 reports name Fluid in thorax; 113 recorded a death outcome (66.1% of reported events, not a population-level mortality rate). VeDDRA code: 1183.

By species: Dog (118 reports), Cat (38 reports), Cattle (13 reports). By breed: Domestic Shorthair (25), Retriever - Labrador (11), Chihuahua (7).

Most co-reported drugs: Milbemycin Oxime + Spinosad (19 reports), Furosemide (17 reports), Carprofen (13 reports), Prednisone (13 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.