Reaction profile

The FDA adverse-event record for joint inflammation

109 FDA adverse-event reports reference joint inflammation (VeDDRA 571). See the species, breeds, and drugs most associated with it below.

109
reports citing this reaction
12.8%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
109
Total Reports
14
Deaths
12.8%
Death Rate

Species Most Affected

Dog 66
Horse 37
Cat 3
Human 2
Pig 1

Breeds Most Affected

Quarter Horse 16
Retriever - Golden 10
Shepherd Dog - German 8
Horse (unknown) 7
Crossbred Canine/dog 7
Retriever - Labrador 7
Unknown 4
Thoroughbred 4
Boxer (German Boxer) 3
Pit Bull 3

Associated Drugs

Carprofen 18
Hyaluronate Sodium 17
Triamcinolone Acetonide 13
Bedinvetmab 11
Milbemycin Oxime + Spinosad 9
Grapiprant 8
Milbemycin Oxime + Praziquantel 6
Afoxolaner 5
Prednisone 5
Enrofloxacin 4
Amikacin 4
Oclacitinib Maleate 4
Hyaluronic Acid 4
Trilostane 4
Lotilaner 4
Methylprednisolone Acetate 3
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 3
Phenylpropanolamine 3
Fluralaner Chew Tablets 3
Gabapentin 3

Joint inflammation Reaction Insights

109 reports name Joint inflammation; 14 recorded a death outcome (12.8% of reported events, not a population-level mortality rate). VeDDRA code: 571.

By species: Dog (66 reports), Horse (37 reports), Cat (3 reports). By breed: Quarter Horse (16), Retriever - Golden (10), Shepherd Dog - German (8).

Most co-reported drugs: Carprofen (18 reports), Hyaluronate Sodium (17 reports), Triamcinolone Acetonide (13 reports), Bedinvetmab (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.