Reaction profile

The FDA adverse-event record for joint inflammation

115 FDA adverse-event reports reference joint inflammation (VeDDRA 571). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1325 of 2,481
by report volume (all reactions)
115
reports citing this reaction
15.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Joint inflammation has 115 reports now versus 110 in that prior snapshot: 5 more (4.5%).

Report change
+5
Death-coded reports
+3
Death-coded share
+2.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Joint inflammation changes

FDA AER · VeDDRA plate

Code 571 VOL-LOW

VOL-LOW · DEATH-ELEV · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 115 reports
  • DEATH-ELEV 15.7%
  • MID-PACK #1325/2481
  • PHOTO-FINISH Elevated betahydroxyb…
  • SPECIES-DOG Dog · 66
  • DRUG-LEAD Hyaluronate Sodium · 21
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated betahydroxybutyrate (BHBA) (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Joint inflammation

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Elevated betahydroxyb… · near115Joint inflammation · this re…115Physical label damaged · near115Uncontrolled diabetes · near115Abdominal cramp · near114Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Joint inflammation

What the FDA AER plate says about Joint inflammation

Signature read: report volume at 115 (#1325 of 2,481) is the standout scale stamp on Joint inflammation. Report volume sits in the middle third of the reaction corpus. 18 of 115 reports were death-coded (15.7% of named reports, not a population mortality rate). Nearest volume peer: Elevated betahydroxybutyrate (BHBA) (±0 reports). Lead species Dog (66). Lead co-reported drug Hyaluronate Sodium (21).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Hyaluronate Sodium appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 66
Horse 43
Cat 3
Human 2
Pig 1

Breeds Most Affected

Quarter Horse 17
Retriever - Golden 10
Shepherd Dog - German 8
Horse (unknown) 7
Crossbred Canine/dog 7
Retriever - Labrador 7
Unknown 6
Thoroughbred 4
Boxer (German Boxer) 3
Pit Bull 3

Associated Drugs

Hyaluronate Sodium 21
Carprofen 18
Triamcinolone Acetonide 13
Bedinvetmab 11
Milbemycin Oxime + Spinosad 9
Grapiprant 8
Milbemycin Oxime + Praziquantel 6
Amikacin 5
Afoxolaner 5
Prednisone 5
Enrofloxacin 4
Oclacitinib Maleate 4
Hyaluronic Acid 4
Trilostane 4
Lotilaner 4
Methylprednisolone Acetate 3
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 3
Phenylpropanolamine 3
Fluralaner Chew Tablets 3
Gabapentin 3

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Joint inflammation, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (15.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Joint inflammation (#1325 of 2,481 by report volume); death-coded 15.7%. PlainBreed reaction plate · report volume stamp 115 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →