Reaction profile

The FDA adverse-event record for claw / hoof / nail disorder nos

259 FDA adverse-event reports reference claw / hoof / nail disorder nos (VeDDRA 1919). See the species, breeds, and drugs most associated with it below.

259
reports citing this reaction
15.8%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
259
Total Reports
41
Deaths
15.8%
Death Rate

Species Most Affected

Dog 155
Cattle 36
Horse 28
Cat 27
Pig 5
Human 5
Other Camelids 1
Chicken 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 14
Retriever - Labrador 13
Shepherd Dog - German 12
Retriever - Golden 11
Crossbred Bovine/Cattle 10
Cattle (unknown) 8
Holstein-Friesian also known as Holstein 7
Crossbred Canine/dog 7
Quarter Horse 7
Pit Bull 6

Associated Drugs

Oclacitinib Maleate 32
Bedinvetmab 23
Milbemycin Oxime + Spinosad 18
Carprofen 16
Pergolide Mesylate 15
Afoxolaner 14
Tylosin Phosphate 13
Fluralaner Chew Tablets 11
Moxidectin 10
Anti-Il31 Mab Mcs Lot #1283563 10
Monensin Sodium 9
Milbemycin Oxime + Praziquantel 9
Cefovecin Sodium 8
Zilpaterol 8
Cyclosporine 8
Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine 8
Cefovecin 7
Ivermectin + Pyrantel As Pamoate Salt 7
Cefpodoxime 7
Gabapentin 7

Claw / hoof / nail disorder NOS Reaction Insights

259 reports name Claw / hoof / nail disorder NOS; 41 recorded a death outcome (15.8% of reported events, not a population-level mortality rate). VeDDRA code: 1919.

By species: Dog (155 reports), Cattle (36 reports), Horse (28 reports). By breed: Domestic Shorthair (14), Retriever - Labrador (13), Shepherd Dog - German (12).

Most co-reported drugs: Oclacitinib Maleate (32 reports), Bedinvetmab (23 reports), Milbemycin Oxime + Spinosad (18 reports), Carprofen (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.