Reaction profile

The FDA adverse-event record for palpable mass nos

599 FDA adverse-event reports reference palpable mass nos (VeDDRA 2000). See the species, breeds, and drugs most associated with it below.

599
reports citing this reaction
23.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
599
Total Reports
139
Deaths
23.2%
Death Rate

Species Most Affected

Dog 552
Cat 44
Horse 3

Breeds Most Affected

Retriever - Labrador 79
Domestic Shorthair 32
Retriever - Golden 28
Boxer (German Boxer) 27
Crossbred Canine/dog 26
Shepherd Dog - German 26
Beagle 17
Chihuahua 16
Dog (unknown) 15
Terrier - Bull - American Pit 15

Associated Drugs

Milbemycin Oxime + Spinosad 154
Oclacitinib Maleate 120
Trilostane 36
Carprofen 35
Milbemycin Oxime + Praziquantel 29
Spinosad 27
Maropitant Citrate 25
Milbemycin Oxime 24
Tramadol 20
Meloxicam 20
Anti-Il31 Mab Mcs Lot #1283563 19
Enrofloxacin 18
Imidacloprid + Moxidectin 17
Gabapentin 15
Moxidectin 15
Grapiprant 15
Cefovecin 14
Ivermectin 13
Prednisone 13
Metronidazole 13

Palpable mass NOS Reaction Insights

599 reports name Palpable mass NOS; 139 recorded a death outcome (23.2% of reported events, not a population-level mortality rate). VeDDRA code: 2000.

By species: Dog (552 reports), Cat (44 reports), Horse (3 reports). By breed: Retriever - Labrador (79), Domestic Shorthair (32), Retriever - Golden (28).

Most co-reported drugs: Milbemycin Oxime + Spinosad (154 reports), Oclacitinib Maleate (120 reports), Trilostane (36 reports), Carprofen (35 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.