Reaction profile

The FDA adverse-event record for lack of efficacy (protozoa) - giardia

606 FDA reports name lack of efficacy (protozoa) - giardia, a high-volume reaction in the CVM extract (VeDDRA 2806). Plate stamps and neighbourhood peers follow.

#571 of 2,481
by report volume (all reactions)
606
reports citing this reaction
0.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lack of efficacy (protozoa) - Giardia has 606 reports now versus 570 in that prior snapshot: 36 more (6.3%).

Report change
+36
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lack of efficacy (protozoa) - Giardia changes

FDA AER · VeDDRA plate

Code 2806 VOL-MID

VOL-MID · DEATH-RARE · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 606 reports
  • DEATH-RARE 0.3%
  • UPPER-Q #571/2481
  • PHOTO-FINISH Joint swelling
  • SPECIES-DOG Dog · 589
  • DRUG-LEAD Ivermectin + Pyra… · 187
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Joint swelling (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lack of efficacy - Giardia

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Found dead · near610Palpable mass NOS · near609Colitis · near608Lack of efficacy (pro… · thi…606Joint swelling · near605Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lack of efficacy (protozoa) - Giardia

Lack of efficacy (protozoa) - Giardia: low death-coded share in the FDA AER plate

Signature read: Lack of efficacy (protozoa) - Giardia's 0.3% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 606 named reports in the openFDA extract. Death-coded share is lower-third: 2 of 606 reports (0.3% of named reports). Nearest volume peer: Joint swelling (±1 reports). Lead species Dog (589). Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt (187).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin + Pyrantel As Pamoate Salt appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 589
Cat 17

Breeds Most Affected

Retriever - Labrador 101
Retriever - Golden 50
Crossbred Canine/dog 28
Shepherd Dog - German 22
Shepherd Dog - Australian 20
Dog (unknown) 18
Beagle 17
Mountain Dog - Bernese 16
Bulldog - French 15
Collie - Border 14

Associated Drugs

Ivermectin + Pyrantel As Pamoate Salt 187
Milbemycin Oxime + Praziquantel 125
Pyrantel Pamoate;Sarolaner 88
Fenbendazol Granules 40
Milbemycin/Lufenuron/Pzq Chew 32
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 28
Moxidectin 23
Fenbendazole 21
Metronidazole 18
Lotilaner 16
Afoxolaner 14
Ivermectin + Pyrantel 12
Fenbendazol Suspension 12
Febantel + Praziquantel + Pyrantel Pamoate 12
Eprinomectin + Esafoxolaner + Praziquantel 12
Imidacloprid + Moxidectin 11
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 11
Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet 10
Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet 10
Milbemycin/Lufenuron Tablets 9

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lack of efficacy (protozoa) - Giardia, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (606 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lack of efficacy (protozoa) - Giardia (#571 of 2,481 by report volume); death-coded 0.3%. PlainBreed reaction plate · death-coded share stamp 0.3% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →