Reaction profile

The FDA adverse-event record for colitis

584 FDA adverse-event reports reference colitis (VeDDRA 265). See the species, breeds, and drugs most associated with it below.

584
reports citing this reaction
19.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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584
Total Reports
113
Deaths
19.3%
Death Rate

Species Most Affected

Dog 498
Horse 50
Cat 24
Cattle 9
Donkey 1
Unknown 1
Monkey 1

Breeds Most Affected

Retriever - Labrador 52
Crossbred Canine/dog 28
Terrier - Yorkshire 27
Retriever - Golden 19
Shih Tzu 19
Spaniel - King Charles Cavalier 18
Chihuahua 17
Pit Bull 17
Shepherd Dog - Australian 16
Dog (unknown) 16

Associated Drugs

Milbemycin Oxime + Spinosad 116
Maropitant Citrate 50
Carprofen 42
Fluralaner Chew Tablets 29
Metronidazole 28
Ivermectin + Pyrantel As Pamoate Salt 27
Grapiprant 27
Milbemycin Oxime + Praziquantel 25
Afoxolaner 23
Spinosad 22
Gabapentin 22
Oclacitinib Maleate 21
Prednisone 18
Trilostane 18
Famotidine 16
Meloxicam 15
Ceftiofur Crystalline Free Acid 15
Moxidectin 15
Polysulfated Glycosaminoglycan 14
Cyclosporine 13

Colitis Reaction Insights

584 reports name Colitis; 113 recorded a death outcome (19.3% of reported events, not a population-level mortality rate). VeDDRA code: 265.

By species: Dog (498 reports), Horse (50 reports), Cat (24 reports). By breed: Retriever - Labrador (52), Crossbred Canine/dog (28), Terrier - Yorkshire (27).

Most co-reported drugs: Milbemycin Oxime + Spinosad (116 reports), Maropitant Citrate (50 reports), Carprofen (42 reports), Fluralaner Chew Tablets (29 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.