Reaction profile

The FDA adverse-event record for intervertebral disc disease

368 FDA adverse-event reports reference intervertebral disc disease (VeDDRA 2579). See the species, breeds, and drugs most associated with it below.

368
reports citing this reaction
23.9%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
368
Total Reports
88
Deaths
23.9%
Death Rate

Species Most Affected

Dog 348
Cat 18
Rabbit 1
Tiger 1

Breeds Most Affected

Crossbred Canine/dog 31
Retriever - Labrador 22
Dachshund (unspecified) 21
Chihuahua 18
Bulldog - French 16
Dachshund - Miniature 15
Retriever - Golden 13
Beagle 13
Domestic Shorthair 13
Maltese 11

Associated Drugs

Bedinvetmab 89
Carprofen 40
Gabapentin 39
Fluralaner Chew Tablets 34
Trilostane 32
Fluralaner 13.64% 12-Week Chew 28
Milbemycin Oxime + Spinosad 24
Grapiprant 22
Afoxolaner 20
Moxidectin 19
Maropitant Citrate 19
Milbemycin Oxime + Praziquantel 19
Oclacitinib Maleate 14
Frunevetmab 13
Prednisone 12
Ivermectin + Pyrantel As Pamoate Salt 11
Methocarbamol 11
Sarolaner 9
Pyrantel Pamoate;Sarolaner 9
Anti-Il31 Mab Mcs Lot #1283563 7

Intervertebral disc disease Reaction Insights

368 reports name Intervertebral disc disease; 88 recorded a death outcome (23.9% of reported events, not a population-level mortality rate). VeDDRA code: 2579.

By species: Dog (348 reports), Cat (18 reports), Rabbit (1 reports). By breed: Crossbred Canine/dog (31), Retriever - Labrador (22), Dachshund (unspecified) (21).

Most co-reported drugs: Bedinvetmab (89 reports), Carprofen (40 reports), Gabapentin (39 reports), Fluralaner Chew Tablets (34 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.