Reaction profile

The FDA adverse-event record for decreased percentage of reticulocytes

347 FDA adverse-event reports reference decreased percentage of reticulocytes (VeDDRA 2212). See the species, breeds, and drugs most associated with it below.

347
reports citing this reaction
21.6%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
347
Total Reports
75
Deaths
21.6%
Death Rate

Species Most Affected

Dog 291
Cat 56

Breeds Most Affected

Retriever - Labrador 41
Domestic Shorthair 35
Crossbred Canine/dog 23
Retriever - Golden 21
Shepherd Dog - German 13
Boxer (German Boxer) 12
Shih Tzu 9
Siberian Husky 9
Dachshund (unspecified) 8
Shepherd Dog - Australian 8

Associated Drugs

Oclacitinib Maleate 50
Afoxolaner 43
Maropitant Citrate 40
Carprofen 33
Gabapentin 27
Prednisone 26
Ilunocitinib 23
Ivermectin + Pyrantel As Pamoate Salt 22
Lotilaner 22
Milbemycin Oxime + Praziquantel 21
Doxycycline 20
Bedinvetmab 19
Meloxicam 16
Milbemycin Oxime + Spinosad 15
Cyclosporine 15
Metronidazole 15
Cefovecin 13
Buprenorphine 13
Enrofloxacin 12
Moxidectin 12

Decreased percentage of reticulocytes Reaction Insights

347 reports name Decreased percentage of reticulocytes; 75 recorded a death outcome (21.6% of reported events, not a population-level mortality rate). VeDDRA code: 2212.

By species: Dog (291 reports), Cat (56 reports). By breed: Retriever - Labrador (41), Domestic Shorthair (35), Crossbred Canine/dog (23).

Most co-reported drugs: Oclacitinib Maleate (50 reports), Afoxolaner (43 reports), Maropitant Citrate (40 reports), Carprofen (33 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.