Reaction profile

The FDA adverse-event record for inappropriate preparation of medication

144 FDA adverse-event reports reference inappropriate preparation of medication (VeDDRA 99831). See the species, breeds, and drugs most associated with it below.

144
reports citing this reaction
25.0%
death-coded share
Dog
most-affected species
Monensin
most-associated drug
Verify with FDA CVM →
144
Total Reports
36
Deaths
25.0%
Death Rate

Species Most Affected

Dog 65
Cat 23
Cattle 20
Turkey 10
Unknown 9
Chicken 7
Human 3
Pig 2
Sheep 1
Quail 1

Breeds Most Affected

Unknown 15
Domestic Shorthair 12
Crossbred Canine/dog 11
Turkey (unknown) 10
Crossbred Bovine/Cattle 8
Chicken (unknown) 7
Cattle (unknown) 7
Dog (unknown) 6
Retriever - Labrador 5
Chihuahua 4

Associated Drugs

Monensin 24
Nitenpyram 13
Milbemycin Oxime + Spinosad 13
Dexmedetomidine Hydrochloride 10
Spinosad 7
Insulin Injectable Vial 7
Imidacloprid + Moxidectin 6
Butorphanol 6
Narasin, Nicarbazin 5
Tiletamine Hcl; Zolazapam Hcl 5
Trilostane 5
Fenbendazol Granules 5
Lasalocid 4
Carprofen 4
Melengestrol Acetate 3
Selamectin 3
Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate) 3
Butorphanol Injectable 3
Ivermectin + Pyrantel As Pamoate Salt 3
Afoxolaner 3

Inappropriate preparation of medication Reaction Insights

144 reports name Inappropriate preparation of medication; 36 recorded a death outcome (25.0% of reported events, not a population-level mortality rate). VeDDRA code: 99831.

By species: Dog (65 reports), Cat (23 reports), Cattle (20 reports). By breed: Unknown (15), Domestic Shorthair (12), Crossbred Canine/dog (11).

Most co-reported drugs: Monensin (24 reports), Nitenpyram (13 reports), Milbemycin Oxime + Spinosad (13 reports), Dexmedetomidine Hydrochloride (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.