Reaction profile

The FDA adverse-event record for respiratory tract infection nos

387 FDA adverse-event reports reference respiratory tract infection nos (VeDDRA 1182). See the species, breeds, and drugs most associated with it below.

387
reports citing this reaction
20.2%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
387
Total Reports
78
Deaths
20.2%
Death Rate

Species Most Affected

Dog 179
Cat 168
Cattle 27
Horse 3
Human 3
Chicken 2
Rat 1
Rabbit 1
Other Birds 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 97
Retriever - Labrador 15
Domestic Longhair 14
Cat (unknown) 13
Crossbred Canine/dog 13
Domestic Mediumhair 11
Shih Tzu 11
Cat (other) 9
Boxer (German Boxer) 7
Maine Coon 6

Associated Drugs

Milbemycin Oxime + Spinosad 59
Imidacloprid + Moxidectin 24
Oclacitinib Maleate 24
Trilostane 22
Cefovecin 21
Enrofloxacin 19
Spinosad 14
Selamectin 13
Doxycycline 13
Gabapentin 12
Amoxicillin + Clavulanic Acid 12
Cyclosporine 11
Moxidectin 11
Maropitant Citrate 11
Meloxicam 10
Pradofloxacin 10
Frunevetmab 10
Bexagliflozin 9
Azithromycin 9
Bedinvetmab 9

Respiratory tract infection NOS Reaction Insights

387 reports name Respiratory tract infection NOS; 78 recorded a death outcome (20.2% of reported events, not a population-level mortality rate). VeDDRA code: 1182.

By species: Dog (179 reports), Cat (168 reports), Cattle (27 reports). By breed: Domestic Shorthair (97), Retriever - Labrador (15), Domestic Longhair (14).

Most co-reported drugs: Milbemycin Oxime + Spinosad (59 reports), Imidacloprid + Moxidectin (24 reports), Oclacitinib Maleate (24 reports), Trilostane (22 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.