Reaction profile

The FDA adverse-event record for blindness

2,558 FDA reports name blindness, a high-volume reaction in the CVM extract (VeDDRA 406). Plate stamps and neighbourhood peers follow.

#185 of 2,481
by report volume (all reactions)
2,558
reports citing this reaction
24.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Blindness has 2,558 reports now versus 2,513 in that prior snapshot: 45 more (1.8%).

Report change
+45
Death-coded reports
+13
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Blindness changes

FDA AER · VeDDRA plate

Code 406 VOL-MID

VOL-MID · DEATH-HOT · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 2,558 reports
  • DEATH-HOT 24.3%
  • TOP-DECILE #185/2481
  • PHOTO-FINISH Application site eryt…
  • SPECIES-DOG Dog · 1,754
  • DRUG-LEAD Milbemycin Oxime… · 182
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site erythema (±2 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Blindness

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Dermatitis · near2569Blindness · this reaction2558Application site eryt… · near2556Limping · near2549Systemic disorder NOS · near2540Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Blindness

Blindness: high death-coded share in the FDA AER plate

Signature read: 622 death-coded reports is a heavy tail count for Blindness in the CVM extract. Report volume is upper-third scale: 2,558 named reports in the openFDA extract. Death-coded share is upper-third: 622 of 2,558 reports (24.3% of named reports). Nearest volume peer: Application site erythema (±2 reports). Lead species Dog (1,754). Lead co-reported drug Milbemycin Oxime + Spinosad (182).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,754
Cat 727
Cattle 44
Horse 20
Goat 3
Human 3
Chicken 3
Sheep 2
Bobcat 1
Ferret 1

Breeds Most Affected

Domestic Shorthair 342
Crossbred Canine/dog 137
Retriever - Labrador 121
Domestic (unspecified) 106
Dog (unknown) 100
Terrier - Yorkshire 84
Chihuahua 82
Shih Tzu 65
Cat (unknown) 64
Shepherd Dog - German 51

Associated Drugs

Milbemycin Oxime + Spinosad 182
Ivermectin 164
Enrofloxacin 150
Spinosad 141
Carprofen 116
Trilostane 102
Cefovecin 99
Maropitant Citrate 98
Bedinvetmab 93
Buprenorphine 78
Fluralaner Chew Tablets 74
Isoflurane 71
Frunevetmab 71
Afoxolaner 67
Moxidectin 65
Meloxicam 61
Fluralaner 13.64% 12-Week Chew 59
Oclacitinib Maleate 58
Selamectin 57
Insulin Injectable Vial 57

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Blindness, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (2,558 here).

Similar death-coded share

Nearest other reactions by death-coded share (24.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Blindness (#185 of 2,481 by report volume); death-coded 24.3%. PlainBreed reaction plate · death-coded report count stamp 622 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →