Reaction profile

The FDA adverse-event record for decreased cholesterol (total)

401 FDA adverse-event reports reference decreased cholesterol (total) (VeDDRA 2265). See the species, breeds, and drugs most associated with it below.

401
reports citing this reaction
27.4%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
401
Total Reports
110
Deaths
27.4%
Death Rate

Species Most Affected

Dog 357
Cat 39
Horse 3
Rabbit 1
Cattle 1

Breeds Most Affected

Retriever - Labrador 43
Crossbred Canine/dog 32
Domestic Shorthair 26
Terrier - Yorkshire 21
Chihuahua 17
Shepherd Dog - German 15
Shih Tzu 10
Siberian Husky 9
Dachshund (unspecified) 9
Retriever - Golden 9

Associated Drugs

Carprofen 43
Oclacitinib Maleate 37
Afoxolaner 35
Fluralaner Chew Tablets 34
Maropitant Citrate 33
Ivermectin + Pyrantel As Pamoate Salt 25
Famotidine 22
Milbemycin Oxime + Spinosad 22
Metronidazole 20
Enrofloxacin 18
Moxidectin 17
Gabapentin 17
Prednisone 17
Doxycycline 15
Rabies Vaccine 14
Maropitant 14
Buprenorphine 13
Meloxicam 13
Tramadol 12
Deracoxib 11

Decreased cholesterol (total) Reaction Insights

401 reports name Decreased cholesterol (total); 110 recorded a death outcome (27.4% of reported events, not a population-level mortality rate). VeDDRA code: 2265.

By species: Dog (357 reports), Cat (39 reports), Horse (3 reports). By breed: Retriever - Labrador (43), Crossbred Canine/dog (32), Domestic Shorthair (26).

Most co-reported drugs: Carprofen (43 reports), Oclacitinib Maleate (37 reports), Afoxolaner (35 reports), Fluralaner Chew Tablets (34 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.