Reaction profile

The FDA adverse-event record for allergic skin reaction

249 FDA adverse-event reports reference allergic skin reaction (VeDDRA 1306). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#940 of 2,481
by report volume (all reactions)
249
reports citing this reaction
4.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Allergic skin reaction has 249 reports now versus 249 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Allergic skin reaction changes

FDA AER · VeDDRA plate

Code 1306 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 249 reports
  • DEATH-LOW 4.0%
  • MID-PACK #940/2481
  • PHOTO-FINISH Increased mortality r…
  • SPECIES-DOG Dog · 219
  • DRUG-LEAD Milbemycin Oxime… · 75
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Increased mortality rate (±1 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Allergic skin reaction

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Increased mortality r… · near250Allergic skin reaction · thi…249Increased sensitivity… · near248INEFFECTIVE, REVERSAL · near248Chronic renal failure · near247Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Allergic skin reaction

Allergic skin reaction: low death-coded share in the FDA AER plate

Signature read: Allergic skin reaction's 4.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 10 of 249 reports (4.0% of named reports). Nearest volume peer: Increased mortality rate (±1 reports). Lead species Dog (219). Lead co-reported drug Milbemycin Oxime + Spinosad (75).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 219
Cat 18
Human 8
Horse 2
Cattle 1
Other 1

Breeds Most Affected

Retriever - Labrador 23
Pit Bull 14
Retriever - Golden 12
Crossbred Canine/dog 12
Unknown 11
Dog (unknown) 11
Shih Tzu 9
Terrier - Jack Russell 7
Domestic Shorthair 7
Chihuahua 7

Associated Drugs

Milbemycin Oxime + Spinosad 75
Milbemycin Oxime + Praziquantel 22
Oclacitinib Maleate 17
Afoxolaner 12
Lufenuron + Milbemycin Oxime 10
Spinosad 9
Lotilaner 9
Pyrantel Pamoate;Sarolaner 9
Fluralaner Chew Tablets 8
Carprofen 8
Prednisone 7
Fluralaner 13.64% 12-Week Chew 7
Cyclosporine 6
Selamectin 6
Ivermectin + Pyrantel As Pamoate Salt 5
Fluralaner 5
Selamectin;Sarolaner 5
Moxidectin 5
Ivermectin 4
Nitenpyram 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Allergic skin reaction, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (4.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Allergic skin reaction (#940 of 2,481 by report volume); death-coded 4.0%. PlainBreed reaction plate · death-coded share stamp 4.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →