Reaction profile

The FDA adverse-event record for limb non-weight bearing

447 FDA adverse-event reports reference limb non-weight bearing (VeDDRA 2768). See the species, breeds, and drugs most associated with it below.

447
reports citing this reaction
15.0%
death-coded share
Dog
most-affected species
Tigilanol Tiglate
most-associated drug
Verify with FDA CVM →
447
Total Reports
67
Deaths
15.0%
Death Rate

Species Most Affected

Dog 413
Cat 30
Horse 3
Alpaca 1

Breeds Most Affected

Retriever - Labrador 57
Boxer (German Boxer) 24
Chihuahua 22
Retriever - Golden 20
Crossbred Canine/dog 19
Pit Bull 19
Dog (unknown) 19
Domestic Shorthair 19
Terrier - Bull - American Pit 13
Bulldog - French 12

Associated Drugs

Tigilanol Tiglate 160
Bedinvetmab 125
Gabapentin 63
Diphenhydramine 38
Carprofen 36
Prednisone 34
Maropitant Citrate 34
Butorphanol 33
Famotidine 30
Dexmedetomidine 25
Grapiprant 25
Buprenorphine 21
Fluralaner 13.64% 12-Week Chew 18
Butorphanol Tartrate 17
Oclacitinib Maleate 16
Propofol 15
Pyrantel Pamoate;Sarolaner 13
Atipamezole Hydrochloride 13
Frunevetmab 11
Amantadine 11

Limb non-weight bearing Reaction Insights

447 reports name Limb non-weight bearing; 67 recorded a death outcome (15.0% of reported events, not a population-level mortality rate). VeDDRA code: 2768.

By species: Dog (413 reports), Cat (30 reports), Horse (3 reports). By breed: Retriever - Labrador (57), Boxer (German Boxer) (24), Chihuahua (22).

Most co-reported drugs: Tigilanol Tiglate (160 reports), Bedinvetmab (125 reports), Gabapentin (63 reports), Diphenhydramine (38 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.