Reaction profile

The FDA adverse-event record for ineffective, seizures

53 FDA reports name ineffective, seizures, a lower-volume reaction in the CVM extract (VeDDRA 99146). Plate stamps and neighbourhood peers follow.

#1708 of 2,481
by report volume (all reactions)
53
reports citing this reaction
9.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, SEIZURES has 53 reports now versus 53 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, SEIZURES changes

FDA AER · VeDDRA plate

Code 99146 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 53 reports
  • DEATH-PAR 9.4%
  • MID-PACK #1708/2481
  • PHOTO-FINISH Bloody foam in mouth…
  • SPECIES-DOG Dog · 45
  • DRUG-LEAD Phenobarbital · 26
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Bloody foam in mouth and nose (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Lower-volume neighbourhood around INEFFECTIVE, SEIZURES

Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Bloody foam in mouth… · near53Decreased skin turgor · near53Easily startled · near53Footpad disorder NOS · near53INEFFECTIVE, SEIZURES · this…53Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, SEIZURES

What the FDA AER plate says about INEFFECTIVE, SEIZURES

Signature read: 5 death-coded reports is a thin tail count for INEFFECTIVE, SEIZURES in the CVM extract. Report volume is lower-third scale: 53 named reports in the openFDA extract. 5 of 53 reports were death-coded (9.4% of named reports, not a population mortality rate). Nearest volume peer: Bloody foam in mouth and nose (±0 reports). Lead species Dog (45). Lead co-reported drug Phenobarbital (26).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Phenobarbital appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 45
Cat 7
Horse 1

Breeds Most Affected

Dog (unknown) 17
Crossbred Canine/dog 6
Cat (unknown) 6
Terrier - Yorkshire 2
Boxer (German Boxer) 2
Retriever - Golden 2
Terrier - Boston 1
Domestic (unspecified) 1
Poodle (unspecified) 1
Terrier - Scottish 1

Associated Drugs

Phenobarbital 26
Potassium Bromide 26
Levetiracetam 9
Zonisamide 8
Levothyroxine 3
S-Adenosylmethionine/Silybin-Phosphatidylcholine Complex 2
Spinosad 1
Glucosamine 1
Glycosaminoglycan Polysulfate 1
Midazolam Hcl 1
Levetiracetam Er 1
Benazepril 1
Pimobendan 1
Polysulfated Glycosaminoglycan 1
Glucosamine Hydrochloride Supplement 1
Omeprazole 1
Gabapentin 1
Cannabidiol Oil 1
Methimazole 1
Topiramate 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, SEIZURES, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (53 here).

Similar death-coded share

Nearest other reactions by death-coded share (9.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, SEIZURES (#1708 of 2,481 by report volume); death-coded 9.4%. PlainBreed reaction plate · death-coded report count stamp 5 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →