Reaction profile

The FDA adverse-event record for whining

496 FDA adverse-event reports reference whining (VeDDRA 2756). See the species, breeds, and drugs most associated with it below.

496
reports citing this reaction
9.5%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
496
Total Reports
47
Deaths
9.5%
Death Rate

Species Most Affected

Dog 490
Cat 6

Breeds Most Affected

Retriever - Labrador 54
Crossbred Canine/dog 42
Shepherd Dog - German 28
Retriever - Golden 26
Dog (unknown) 23
Chihuahua 18
Siberian Husky 13
Pit Bull 13
Shih Tzu 12
Terrier (unspecified) 12

Associated Drugs

Bedinvetmab 74
Pyrantel Pamoate;Sarolaner 57
Carprofen 39
Gabapentin 35
Tigilanol Tiglate 32
Afoxolaner 30
Fluralaner 13.64% 12-Week Chew 28
Ivermectin + Pyrantel As Pamoate Salt 25
Prednisone 24
Melarsomine Dihydrochloride 22
Nitenpyram 21
Buprenorphine 20
Moxidectin 19
Famotidine 19
Diphenhydramine 18
Milbemycin Oxime + Praziquantel 17
Febantel + Praziquantel + Pyrantel Pamoate 16
Grapiprant 16
Maropitant Citrate 16
Trilostane 14

Whining Reaction Insights

496 reports name Whining; 47 recorded a death outcome (9.5% of reported events, not a population-level mortality rate). VeDDRA code: 2756.

By species: Dog (490 reports), Cat (6 reports). By breed: Retriever - Labrador (54), Crossbred Canine/dog (42), Shepherd Dog - German (28).

Most co-reported drugs: Bedinvetmab (74 reports), Pyrantel Pamoate;Sarolaner (57 reports), Carprofen (39 reports), Gabapentin (35 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.