Increased sexual interest

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VeDDRA Code: 2067

199 adverse event reports referencing this reaction

199
Total Reports
42
Deaths
2110.0%
Death Rate

Species Most Affected

Cattle 150
Dog 46
Cat 3

Breeds Most Affected

Mixed (Cattle) 70
Holstein-Friesian also known as Holstein 39
Cattle (unknown) 17
Aberdeen Angus 9
Crossbred Bovine/Cattle 9
Chihuahua 5
Dog (unknown) 3
Crossbred Canine/dog 3
Domestic (unspecified) 2
Beefmaster 2

Associated Drugs

Trenbolone Acetate;Estradiol Benzoate 70
Estradiol Benzoate; Trenbolone Acetate 30
Estradiol, Trenbolone Acetate 24
Estriol 14
Melengestrol Acetate 12
Estradiol 10
Progesterone; Estradiol Benzoate 7
Progesterone;Estradiol Benzoate 6
Estriol Tablets 5
Milbemycin Oxime + Spinosad 4
Trilostane 4
Oclacitinib Maleate 3
Bedinvetmab 3
Zeranol 2
Zilpaterol 2
Desoxycorticosterone Pivalate 2
Tylosin Phosphate 2
Monensin Sodium 2
Prednisone 2
Milbemycin Oxime + Praziquantel 2

Data Summary

Metric Value
Total reports referencing reaction 199
Reports with fatal outcome 42
Case-fatality rate (reported events) 2110.0%
Species observed 3
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2067.

Increased sexual interest Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 199 adverse event reports that reference Increased sexual interest as a reaction term, including 42 reports with a death outcome — a 2110.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2067, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Increased sexual interest appears most frequently in reports for Cattle (150 reports), Dog (46 reports), Cat (3 reports) — with Cattle dominating at 150 entries. Within those species, the breeds most often named alongside this reaction are Mixed (Cattle) (70), Holstein-Friesian also known as Holstein (39), Cattle (unknown) (17). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Increased sexual interest are Trenbolone Acetate;Estradiol Benzoate (70 reports), Estradiol Benzoate; Trenbolone Acetate (30 reports), Estradiol, Trenbolone Acetate (24 reports), Estriol (14 reports), with Trenbolone Acetate;Estradiol Benzoate appearing alongside this reaction in 70 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial