Reaction profile

The FDA adverse-event record for increased sexual interest

199 FDA adverse-event reports reference increased sexual interest (VeDDRA 2067). See the species, breeds, and drugs most associated with it below.

199
reports citing this reaction
21.1%
death-coded share
Cattle
most-affected species
Trenbolone Acetate;Estradiol Benzoate
most-associated drug
Verify with FDA CVM →
199
Total Reports
42
Deaths
21.1%
Death Rate

Species Most Affected

Cattle 150
Dog 46
Cat 3

Breeds Most Affected

Mixed (Cattle) 70
Holstein-Friesian also known as Holstein 39
Cattle (unknown) 17
Aberdeen Angus 9
Crossbred Bovine/Cattle 9
Chihuahua 5
Dog (unknown) 3
Crossbred Canine/dog 3
Domestic (unspecified) 2
Beefmaster 2

Associated Drugs

Trenbolone Acetate;Estradiol Benzoate 70
Estradiol Benzoate; Trenbolone Acetate 30
Estradiol, Trenbolone Acetate 24
Estriol 14
Melengestrol Acetate 12
Estradiol 10
Progesterone; Estradiol Benzoate 7
Progesterone;Estradiol Benzoate 6
Estriol Tablets 5
Milbemycin Oxime + Spinosad 4
Trilostane 4
Oclacitinib Maleate 3
Bedinvetmab 3
Zeranol 2
Zilpaterol 2
Desoxycorticosterone Pivalate 2
Tylosin Phosphate 2
Monensin Sodium 2
Prednisone 2
Milbemycin Oxime + Praziquantel 2

Increased sexual interest Reaction Insights

199 reports name Increased sexual interest; 42 recorded a death outcome (21.1% of reported events, not a population-level mortality rate). VeDDRA code: 2067.

By species: Cattle (150 reports), Dog (46 reports), Cat (3 reports). By breed: Mixed (Cattle) (70), Holstein-Friesian also known as Holstein (39), Cattle (unknown) (17).

Most co-reported drugs: Trenbolone Acetate;Estradiol Benzoate (70 reports), Estradiol Benzoate; Trenbolone Acetate (30 reports), Estradiol, Trenbolone Acetate (24 reports), Estriol (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.