Reaction profile

The FDA adverse-event record for difficulty to rise

611 FDA adverse-event reports reference difficulty to rise (VeDDRA 2726). See the species, breeds, and drugs most associated with it below.

611
reports citing this reaction
21.6%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
611
Total Reports
132
Deaths
21.6%
Death Rate

Species Most Affected

Dog 583
Cat 21
Cattle 2
Horse 2
Unknown 2
Turkey 1

Breeds Most Affected

Retriever - Labrador 115
Retriever - Golden 50
Shepherd Dog - German 41
Crossbred Canine/dog 26
Boxer (German Boxer) 23
Dog (unknown) 16
Terrier - Bull - American Pit 15
Siberian Husky 14
Great Pyrenees 13
Shepherd Dog - Australian 11

Associated Drugs

Bedinvetmab 280
Carprofen 93
Gabapentin 84
Trilostane 53
Prednisone 37
Pyrantel Pamoate;Sarolaner 35
Grapiprant 34
Fluralaner 13.64% 12-Week Chew 29
Polysulfated Glycosaminoglycan 28
Afoxolaner 27
Galliprant 27
Moxidectin 20
Maropitant Citrate 19
Ivermectin + Pyrantel As Pamoate Salt 14
Dasuquin 14
Oclacitinib Maleate 13
Enrofloxacin 13
Sarolaner 12
Anti-Il31 Mab Mcs Lot #1283563 12
Melarsomine Dihydrochloride 11

Difficulty to rise Reaction Insights

611 reports name Difficulty to rise; 132 recorded a death outcome (21.6% of reported events, not a population-level mortality rate). VeDDRA code: 2726.

By species: Dog (583 reports), Cat (21 reports), Cattle (2 reports). By breed: Retriever - Labrador (115), Retriever - Golden (50), Shepherd Dog - German (41).

Most co-reported drugs: Bedinvetmab (280 reports), Carprofen (93 reports), Gabapentin (84 reports), Trilostane (53 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.