Reaction profile

The FDA adverse-event record for loss of voluntary movement

202 FDA adverse-event reports reference loss of voluntary movement (VeDDRA 1597). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1029 of 2,481
by report volume (all reactions)
202
reports citing this reaction
24.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Loss of voluntary movement has 202 reports now versus 196 in that prior snapshot: 6 more (3.1%).

Report change
+6
Death-coded reports
+3
Death-coded share
+0.8 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Loss of voluntary movement changes

FDA AER · VeDDRA plate

Code 1597 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 202 reports
  • DEATH-HOT 24.8%
  • MID-PACK #1029/2481
  • PHOTO-FINISH Increased sexual inte…
  • SPECIES-DOG Dog · 166
  • DRUG-LEAD Afoxolaner · 40
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Increased sexual interest (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Loss of voluntary movement

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Anal irritation · near203Increased sexual inte… · near202Loss of voluntary mov… · thi…202Digestive tract haemo… · near201Disorder of gastroint… · near201Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Loss of voluntary movement

Loss of voluntary movement: high death-coded share in the FDA AER plate

Signature read: 50 death-coded reports is a heavy tail count for Loss of voluntary movement in the CVM extract. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 50 of 202 reports (24.8% of named reports). Nearest volume peer: Increased sexual interest (±0 reports). Lead species Dog (166). Lead co-reported drug Afoxolaner (40).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 166
Cat 25
Cattle 3
Horse 3
Human 2
Turkey 1
Goat 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 18
Domestic Shorthair 16
Retriever - Golden 13
Crossbred Canine/dog 13
Chihuahua 8
Shepherd Dog - German 6
Shepherd Dog - Australian 6
Terrier - Yorkshire 6
Terrier (unspecified) 5
Pug 5

Associated Drugs

Afoxolaner 40
Milbemycin Oxime + Spinosad 24
Bedinvetmab 19
Fluralaner 13.64% 12-Week Chew 18
Ivermectin + Pyrantel As Pamoate Salt 14
Carprofen 10
Divested Synanthic Bolus 9
Pyrantel Pamoate;Sarolaner 9
Gabapentin 8
Buprenorphine 7
Sarolaner 6
Spinosad 5
Selamectin 5
Fluralaner Spot-On Solution 5
Moxidectin 5
Polysulfated Glycosaminoglycan 5
Maropitant Citrate 5
Frunevetmab 5
Ivermectin 4
Prednisone 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Loss of voluntary movement, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (24.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Loss of voluntary movement (#1029 of 2,481 by report volume); death-coded 24.8%. PlainBreed reaction plate · death-coded report count stamp 50 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →