Reaction profile

The FDA adverse-event record for decreased red blood cell count

1,257 FDA adverse-event reports reference decreased red blood cell count (VeDDRA 2157). See the species, breeds, and drugs most associated with it below.

1,257
reports citing this reaction
30.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
1,257
Total Reports
389
Deaths
30.9%
Death Rate

Species Most Affected

Dog 1,038
Cat 198
Horse 19
Ferret 1
Donkey 1

Breeds Most Affected

Retriever - Labrador 139
Domestic Shorthair 128
Crossbred Canine/dog 72
Retriever - Golden 61
Shepherd Dog - German 51
Chihuahua 43
Shih Tzu 33
Pit Bull 26
Maltese 24
Terrier (unspecified) 24

Associated Drugs

Carprofen 114
Fluralaner Chew Tablets 103
Maropitant Citrate 102
Prednisone 94
Afoxolaner 84
Trilostane 73
Oclacitinib Maleate 69
Milbemycin Oxime + Spinosad 62
Ivermectin + Pyrantel As Pamoate Salt 58
Doxycycline 52
Gabapentin 51
Enrofloxacin 51
Cefovecin 47
Moxidectin 45
Famotidine 42
Bedinvetmab 41
Ilunocitinib 41
Meloxicam 40
Polysulfated Glycosaminoglycan 35
Buprenorphine 35

Decreased red blood cell count Reaction Insights

1,257 reports name Decreased red blood cell count; 389 recorded a death outcome (30.9% of reported events, not a population-level mortality rate). VeDDRA code: 2157.

By species: Dog (1,038 reports), Cat (198 reports), Horse (19 reports). By breed: Retriever - Labrador (139), Domestic Shorthair (128), Crossbred Canine/dog (72).

Most co-reported drugs: Carprofen (114 reports), Fluralaner Chew Tablets (103 reports), Maropitant Citrate (102 reports), Prednisone (94 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.