Reaction profile

The FDA adverse-event record for application site itching

748 FDA adverse-event reports reference application site itching (VeDDRA 23). See the species, breeds, and drugs most associated with it below.

748
reports citing this reaction
0.7%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
748
Total Reports
5
Deaths
0.7%
Death Rate

Species Most Affected

Cat 578
Dog 154
Human 14
Donkey 1
Horse 1

Breeds Most Affected

Domestic Shorthair 397
Domestic Longhair 47
Domestic Mediumhair 27
Crossbred Canine/dog 23
Cat (unknown) 20
Maine Coon 17
Cat (other) 16
Unknown 14
Siamese 13
Shih Tzu 10

Associated Drugs

Selamectin 190
Fluralaner Spot-On Solution 144
Selamectin;Sarolaner 138
Fluralaner/Moxidectin Spot-On 69
Eprinomectin + Esafoxolaner + Praziquantel 37
Ivermectin + Pyrantel As Pamoate Salt 28
Fipronil 9.8%/S-Methoprene 8.8%/Cyphenothrin 5.2% Squeeze-On 24
Imidacloprid + Moxidectin 20
Mirtazapine 16
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 13
Emodepside + Praziquantel 12
Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On 10
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 7
Fipronil 10%/S Methoprene 9% Spot On 6
Cefovecin 6
Buprenorphine 6
Cyclosporine 5
Milbemycin Oxime + Praziquantel 5
Cyphenothrin + Fipronil 5
Eprinomectin + Praziquantel 5

Application site itching Reaction Insights

748 reports name Application site itching; 5 recorded a death outcome (0.7% of reported events, not a population-level mortality rate). VeDDRA code: 23.

By species: Cat (578 reports), Dog (154 reports), Human (14 reports). By breed: Domestic Shorthair (397), Domestic Longhair (47), Domestic Mediumhair (27).

Most co-reported drugs: Selamectin (190 reports), Fluralaner Spot-On Solution (144 reports), Selamectin;Sarolaner (138 reports), Fluralaner/Moxidectin Spot-On (69 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.