Reaction profile

The FDA adverse-event record for application site scratching

1,057 FDA adverse-event reports reference application site scratching (VeDDRA 26). See the species, breeds, and drugs most associated with it below.

1,057
reports citing this reaction
0.7%
death-coded share
Cat
most-affected species
Fluralaner Spot-On Solution
most-associated drug
Verify with FDA CVM →
1,057
Total Reports
7
Deaths
0.7%
Death Rate

Species Most Affected

Cat 893
Dog 161
Horse 2
Rabbit 1

Breeds Most Affected

Domestic Shorthair 564
Domestic Mediumhair 72
Domestic Longhair 68
Cat (unknown) 47
Siamese 26
Cat (other) 23
Maine Coon 21
Retriever - Labrador 12
Retriever - Golden 11
Shih Tzu 10

Associated Drugs

Fluralaner Spot-On Solution 274
Selamectin 200
Selamectin;Sarolaner 134
Fluralaner/Moxidectin Spot-On 106
Imidacloprid + Moxidectin 73
Emodepside + Praziquantel 61
Eprinomectin + Esafoxolaner + Praziquantel 40
Fipronil 9.8%/S-Methoprene 8.8%/Cyphenothrin 5.2% Squeeze-On 37
Buprenorphine 31
Ivermectin + Pyrantel As Pamoate Salt 27
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 22
Imidacloprid, Flumethrin 17
Mirtazapine 14
Fipronil 10%/S Methoprene 9% Spot On 10
Nitenpyram 9
Cefovecin 8
Imidacloprid + Pyriproxyfen 8
Florfenicol, Terbinafine, Betamethasone Acetate 8
Flumethrin-Imidacloprid 7
Dexmedetomidine 7

Application site scratching Reaction Insights

1,057 reports name Application site scratching; 7 recorded a death outcome (0.7% of reported events, not a population-level mortality rate). VeDDRA code: 26.

By species: Cat (893 reports), Dog (161 reports), Horse (2 reports). By breed: Domestic Shorthair (564), Domestic Mediumhair (72), Domestic Longhair (68).

Most co-reported drugs: Fluralaner Spot-On Solution (274 reports), Selamectin (200 reports), Selamectin;Sarolaner (134 reports), Fluralaner/Moxidectin Spot-On (106 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.