Reaction profile

The FDA adverse-event record for drug device difficult to use/handle

Name: Drug device difficult to use/handle - FDA Animal Adverse Reaction
Creator: PlainBreed
License: https://open.fda.gov/license/

163 FDA adverse-event reports reference drug device difficult to use/handle (VeDDRA 93090). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1142 of 2,481
by report volume (all reactions): 163
reports citing this reaction: 0.6%
death-coded share: Unknown
most-affected species

Compiled by PlainBreed

Verify with FDA CVM →

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Drug device difficult to use/handle has 163 reports now versus 159 in that prior snapshot: 4 more (2.5%).

Report change: +4
Death-coded reports: +0
Death-coded share: −0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Drug device difficult to use/handle changes

FDA AER · VeDDRA plate

Code 93090 VOL-LOW

VOL-LOW · DEATH-RARE · MID-PACK · PHOTO-FINISH · SPECIES-UNKNOWN · DRUG-LEAD · DESK-WIDE · BOOK-FULL

VOL-LOW 163 reports
DEATH-RARE 0.6%
MID-PACK #1142/2481
PHOTO-FINISH Bronchopneumonia
SPECIES-UNKNOWN Unknown · 131
DRUG-LEAD Pyrantel Pamoate;… · 116
DESK-WIDE 19 breeds
BOOK-FULL 8/8 fields

Nearest volume peer: Bronchopneumonia (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Drug device difficult to use/handle

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

FDA AER report volume · neighbourhood around Drug device difficult to use/handle

Drug device difficult to use/handle: low death-coded share in the FDA AER plate

Signature read: Drug device difficult to use/handle's 0.6% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 1 of 163 reports (0.6% of named reports). Nearest volume peer: Bronchopneumonia (±0 reports). Lead species Unknown (131). Lead co-reported drug Pyrantel Pamoate;Sarolaner (116).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Pyrantel Pamoate;Sarolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 131

Dog 28

Human 2

Cat 2

Breeds Most Affected

Unknown 133

Retriever - Labrador 5

Dog (unknown) 3

Terrier (unspecified) 2

Terrier - Boston 2

Retriever - Golden 2

Dachshund (unspecified) 2

Cat (unknown) 2

Terrier - Bull - American Pit 2

Portuguese Water Dog 1

Associated Drugs

Pyrantel Pamoate;Sarolaner 116

Oclacitinib Maleate 12

Sarolaner 8

Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 4

Moxidectin 3

Cyclosporine 3

Vetpen Starter Kit 2

Sodium Hyaluronate 2

Fluralaner Powder For Inj Susp 2

Device: Syringe 1

Meloxicam 1

Eprinomectin + Esafoxolaner + Praziquantel 1

Lamotrigine 1

Levothyroxine 1

Amoxicillin 1

Rabacfosadine 1

Bexagliflozin 1

Insulin (Unknown) 1

Carprofen 1

Epsiprantel 1

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Drug device difficult to use/handle, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (163 here).

Bronchopneumonia 163 Retinal detachment 163 Dazed 162 Haemolysis NOS 162

Similar death-coded share

Nearest other reactions by death-coded share (0.6% here), distinct from the volume row.

Lack of efficacy (bacteria) - Borrelia 0.6% Implant, Abnormal 0.6% Lack of efficacy (bacteria) - Anaplasma 0.6% Application site hair loss 0.6%

What to do with this reaction

Compare Drug device difficult to use/handle's report profile against similar reactions nationwide. See similar reactions
Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
Browse the full reaction directory to compare report counts across reaction types. All reactions

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Drug device difficult to use/handle (#1142 of 2,481 by report volume); death-coded 0.6%. PlainBreed reaction plate · death-coded share stamp 0.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →