Reaction profile

The FDA adverse-event record for injection site ulcer

190 FDA adverse-event reports reference injection site ulcer (VeDDRA 106). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1069 of 2,481
by report volume (all reactions)
190
reports citing this reaction
8.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Injection site ulcer has 190 reports now versus 181 in that prior snapshot: 9 more (5.0%).

Report change
+9
Death-coded reports
+0
Death-coded share
−0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Injection site ulcer changes

FDA AER · VeDDRA plate

Code 106 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 190 reports
  • DEATH-PAR 8.4%
  • MID-PACK #1069/2481
  • PHOTO-FINISH Capsules, Abnormal
  • SPECIES-DOG Dog · 148
  • DRUG-LEAD Tigilanol Tiglate · 75
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Capsules, Abnormal (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Injection site ulcer

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Bloody stool · near191Decreased pulse oxyge… · near191Dizziness · near191Capsules, Abnormal · near190Injection site ulcer · this …190Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Injection site ulcer

What the FDA AER plate says about Injection site ulcer

Signature read: death-coded share at 8.4% is the most distinctive outcome stamp on Injection site ulcer. Report volume sits in the middle third of the reaction corpus. 16 of 190 reports were death-coded (8.4% of named reports, not a population mortality rate). Nearest volume peer: Capsules, Abnormal (±0 reports). Lead species Dog (148). Lead co-reported drug Tigilanol Tiglate (75).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Tigilanol Tiglate appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 148
Cat 33
Mouse 2
Goat 2
Cattle 1
Rat 1
Bat 1
Rabbit 1
Pig 1

Breeds Most Affected

Retriever - Labrador 19
Domestic Shorthair 17
Boxer (German Boxer) 14
Pit Bull 9
Retriever - Golden 9
Terrier - Bull - American Pit 7
Dachshund (unspecified) 6
Dog (unknown) 6
Beagle 4
Chihuahua 4

Associated Drugs

Tigilanol Tiglate 75
Famotidine 34
Diphenhydramine 31
Carprofen 30
Dexmedetomidine 27
Prednisone 27
Gabapentin 25
Maropitant Citrate 22
Butorphanol 22
Butorphanol Tartrate 14
Cefovecin 12
Moxidectin 12
Atipamezole 12
Atipamezole Hydrochloride 12
Dexmedetomidine Hydrochloride 11
Propofol 9
Frunevetmab 9
Enrofloxacin 8
Buprenorphine 8
Isoflurane 6

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Injection site ulcer, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (190 here).

Similar death-coded share

Nearest other reactions by death-coded share (8.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Injection site ulcer (#1069 of 2,481 by report volume); death-coded 8.4%. PlainBreed reaction plate · death-coded share stamp 8.4% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →