Reaction profile

The FDA adverse-event record for urination related to convulsion

356 FDA adverse-event reports reference urination related to convulsion (VeDDRA 2772). See the species, breeds, and drugs most associated with it below.

356
reports citing this reaction
8.7%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
356
Total Reports
31
Deaths
8.7%
Death Rate

Species Most Affected

Dog 337
Cat 19

Breeds Most Affected

Crossbred Canine/dog 45
Retriever - Labrador 33
Retriever - Golden 26
Shih Tzu 14
Shepherd Dog - Australian 14
Shepherd Dog - German 13
Domestic Shorthair 13
Pit Bull 9
Chihuahua 8
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 8

Associated Drugs

Afoxolaner 101
Fluralaner 13.64% 12-Week Chew 87
Ivermectin + Pyrantel As Pamoate Salt 52
Pyrantel Pamoate;Sarolaner 17
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 13
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 13
Gabapentin 11
Sarolaner 9
Oclacitinib Maleate 9
Milbemycin Oxime + Spinosad 8
Fluralaner Spot-On Solution 8
Milbemycin Oxime + Praziquantel 8
Moxidectin 6
Milbemycin/Lufenuron/Pzq Chew 6
Eprinomectin + Esafoxolaner + Praziquantel 6
Doxycycline 5
Fluralaner 5.46% 1-Month Chew 5
Bedinvetmab 5
Insulin Injectable Vial 4
Lotilaner 4

Urination related to convulsion Reaction Insights

356 reports name Urination related to convulsion; 31 recorded a death outcome (8.7% of reported events, not a population-level mortality rate). VeDDRA code: 2772.

By species: Dog (337 reports), Cat (19 reports). By breed: Crossbred Canine/dog (45), Retriever - Labrador (33), Retriever - Golden (26).

Most co-reported drugs: Afoxolaner (101 reports), Fluralaner 13.64% 12-Week Chew (87 reports), Ivermectin + Pyrantel As Pamoate Salt (52 reports), Pyrantel Pamoate;Sarolaner (17 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.