Urination related to convulsion

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VeDDRA Code: 2772

356 adverse event reports referencing this reaction

356
Total Reports
31
Deaths
870.0%
Death Rate

Species Most Affected

Dog 337
Cat 19

Breeds Most Affected

Crossbred Canine/dog 45
Retriever - Labrador 33
Retriever - Golden 26
Shih Tzu 14
Shepherd Dog - Australian 14
Shepherd Dog - German 13
Domestic Shorthair 13
Pit Bull 9
Chihuahua 8
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 8

Associated Drugs

Afoxolaner 101
Fluralaner 13.64% 12-Week Chew 87
Ivermectin + Pyrantel As Pamoate Salt 52
Pyrantel Pamoate;Sarolaner 17
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 13
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 13
Gabapentin 11
Sarolaner 9
Oclacitinib Maleate 9
Milbemycin Oxime + Spinosad 8
Fluralaner Spot-On Solution 8
Milbemycin Oxime + Praziquantel 8
Moxidectin 6
Milbemycin/Lufenuron/Pzq Chew 6
Eprinomectin + Esafoxolaner + Praziquantel 6
Doxycycline 5
Fluralaner 5.46% 1-Month Chew 5
Bedinvetmab 5
Insulin Injectable Vial 4
Lotilaner 4

Data Summary

Metric Value
Total reports referencing reaction 356
Reports with fatal outcome 31
Case-fatality rate (reported events) 870.0%
Species observed 2
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2772.

Urination related to convulsion Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 356 adverse event reports that reference Urination related to convulsion as a reaction term, including 31 reports with a death outcome — a 870.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2772, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Urination related to convulsion appears most frequently in reports for Dog (337 reports), Cat (19 reports) — with Dog dominating at 337 entries. Within those species, the breeds most often named alongside this reaction are Crossbred Canine/dog (45), Retriever - Labrador (33), Retriever - Golden (26). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Urination related to convulsion are Afoxolaner (101 reports), Fluralaner 13.64% 12-Week Chew (87 reports), Ivermectin + Pyrantel As Pamoate Salt (52 reports), Pyrantel Pamoate;Sarolaner (17 reports), with Afoxolaner appearing alongside this reaction in 101 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial