Reaction profile

The FDA adverse-event record for urination related to convulsion

391 FDA reports name urination related to convulsion, a high-volume reaction in the CVM extract (VeDDRA 2772). Plate stamps and neighbourhood peers follow.

#739 of 2,481
by report volume (all reactions)
391
reports citing this reaction
8.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Urination related to convulsion has 391 reports now versus 376 in that prior snapshot: 15 more (4.0%).

Report change
+15
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Urination related to convulsion changes

FDA AER · VeDDRA plate

Code 2772 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 391 reports
  • DEATH-PAR 8.4%
  • MID-PACK #739/2481
  • PHOTO-FINISH Basophilia
  • SPECIES-DOG Dog · 372
  • DRUG-LEAD Afoxolaner · 106
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Basophilia (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Urination related to convulsion

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Stranguria · near392Basophilia · near391Urination related to… · this…391Fasciculation · near390Application site sore · near389Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Urination related to convulsion

Signature read: 391 reports place Urination related to convulsion in the upper third of FDA AER volume (#739 of 2,481). Report volume is upper-third scale: 391 named reports in the openFDA extract. 33 of 391 reports were death-coded (8.4% of named reports, not a population mortality rate). Nearest volume peer: Basophilia (±0 reports). Lead species Dog (372). Lead co-reported drug Afoxolaner (106).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 372
Cat 19

Breeds Most Affected

Crossbred Canine/dog 47
Retriever - Labrador 35
Retriever - Golden 29
Shepherd Dog - Australian 15
Shih Tzu 14
Shepherd Dog - German 14
Domestic Shorthair 13
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog) 10
Pit Bull 10
Chihuahua 9

Associated Drugs

Afoxolaner 106
Fluralaner 13.64% 12-Week Chew 90
Ivermectin + Pyrantel As Pamoate Salt 52
Pyrantel Pamoate;Sarolaner 20
Afoxolaner 75Mg / Moxidectin 360Mcg / Pyrantel 150Mg Chewable Tablet 16
Afoxolaner 150Mg / Moxidectin 720Mcg / Pyrantel 300Mg Chewable Tablet 15
Gabapentin 12
Milbemycin Oxime + Spinosad 11
Sarolaner 9
Oclacitinib Maleate 9
Milbemycin Oxime + Praziquantel 9
Fluralaner Spot-On Solution 9
Milbemycin/Lufenuron/Pzq Chew 7
Bedinvetmab 7
Afoxolaner 18.75Mg / Moxidectin 90Mcg / Pyrantel 37.5Mg Chewable Tablet 7
Moxidectin 6
Afoxolaner 37.5Mg / Moxidectin 180Mcg / Pyrantel 75Mg Chewable Tablet 6
Eprinomectin + Esafoxolaner + Praziquantel 6
Doxycycline 5
Fluralaner 5.46% 1-Month Chew 5

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Urination related to convulsion, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (391 here).

Similar death-coded share

Nearest other reactions by death-coded share (8.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Urination related to convulsion (#739 of 2,481 by report volume); death-coded 8.4%. PlainBreed reaction plate · report volume stamp 391 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →