Reaction profile

The FDA adverse-event record for hypocortisolaemia

469 FDA adverse-event reports reference hypocortisolaemia (VeDDRA 2625). See the species, breeds, and drugs most associated with it below.

469
reports citing this reaction
4.9%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
469
Total Reports
23
Deaths
4.9%
Death Rate

Species Most Affected

Dog 469

Breeds Most Affected

Retriever - Labrador 55
Maltese 22
Beagle 20
Crossbred Canine/dog 18
Chihuahua 18
Shih Tzu 16
Terrier (unspecified) 16
Terrier - Boston 15
Retriever - Golden 14
Dog (unknown) 13

Associated Drugs

Trilostane 620
Gabapentin 21
Oclacitinib Maleate 19
Carprofen 14
Pimobendan 13
Prednisone 12
Grapiprant 11
Amlodipine 11
Afoxolaner 10
Ursodiol 10
Maropitant Citrate 10
Insulin 9
Insulin Injectable Vial 8
Anti-Il31 Mab Mcs Lot #1283563 7
Enalapril 7
Ivermectin + Pyrantel As Pamoate Salt 7
Desoxycortone Pivalate 7
Metronidazole 7
Oclacitinib 6
Cefpodoxime Proxetil 6

Hypocortisolaemia Reaction Insights

469 reports name Hypocortisolaemia; 23 recorded a death outcome (4.9% of reported events, not a population-level mortality rate). VeDDRA code: 2625.

By species: Dog (469 reports). By breed: Retriever - Labrador (55), Maltese (22), Beagle (20).

Most co-reported drugs: Trilostane (620 reports), Gabapentin (21 reports), Oclacitinib Maleate (19 reports), Carprofen (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.