Reaction profile

The FDA adverse-event record for retching

2,093 FDA adverse-event reports reference retching (VeDDRA 345). See the species, breeds, and drugs most associated with it below.

2,093
reports citing this reaction
8.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
2,093
Total Reports
175
Deaths
8.4%
Death Rate

Species Most Affected

Dog 1,809
Cat 275
Human 6
Horse 1
Unknown 1
Other Mustelids 1

Breeds Most Affected

Retriever - Labrador 172
Crossbred Canine/dog 147
Domestic Shorthair 143
Chihuahua 106
Terrier - Yorkshire 84
Retriever - Golden 77
Shih Tzu 60
Boxer (German Boxer) 59
Maltese 57
Shepherd Dog - German 55

Associated Drugs

Milbemycin Oxime + Spinosad 362
Spinosad 163
Afoxolaner 132
Fluralaner Chew Tablets 100
Ivermectin + Pyrantel As Pamoate Salt 84
Pyrantel Pamoate;Sarolaner 73
Maropitant Citrate 72
Moxidectin 64
Imidacloprid + Moxidectin 64
Carprofen 61
Milbemycin Oxime + Praziquantel 58
Febantel + Praziquantel + Pyrantel Pamoate 44
Selamectin 40
Oclacitinib Maleate 39
Fenbendazole 36
Nitenpyram 36
Meloxicam 34
Bedinvetmab 34
Fluralaner 13.64% 12-Week Chew 32
Grapiprant 31

Retching Reaction Insights

2,093 reports name Retching; 175 recorded a death outcome (8.4% of reported events, not a population-level mortality rate). VeDDRA code: 345.

By species: Dog (1,809 reports), Cat (275 reports), Human (6 reports). By breed: Retriever - Labrador (172), Crossbred Canine/dog (147), Domestic Shorthair (143).

Most co-reported drugs: Milbemycin Oxime + Spinosad (362 reports), Spinosad (163 reports), Afoxolaner (132 reports), Fluralaner Chew Tablets (100 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.