Reaction profile
The FDA adverse-event record for hypersensitivity to pain
52 FDA reports name hypersensitivity to pain, a lower-volume reaction in the CVM extract (VeDDRA 703). Plate stamps and neighbourhood peers follow.
- #1716 of 2,481
- by report volume (all reactions)
- 52
- reports citing this reaction
- 9.6%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hypersensitivity to pain has 52 reports now versus 50 in that prior snapshot: 2 more (4.0%).
- Report change
- +2
- Death-coded reports
- +2
- Death-coded share
- +3.6 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Hypersensitivity to pain changesFDA AER · VeDDRA plate
Code 703 VOL-LOW
VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-LOW 52 reports
- DEATH-PAR 9.6%
- MID-PACK #1716/2481
- PHOTO-FINISH Decreased intra-ocula…
- SPECIES-DOG Dog · 42
- DRUG-LEAD Milbemycin Oxime… · 13
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: Decreased intra-ocular pressure (±0 reports)
Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.
Lower-volume neighbourhood around Hypersensitivity to pain
Lower-third volume poles plus nearest peers, not a full reaction corpus board reprint.
What the FDA AER plate says about Hypersensitivity to pain
Signature read: 5 death-coded reports is a thin tail count for Hypersensitivity to pain in the CVM extract. Report volume is lower-third scale: 52 named reports in the openFDA extract. 5 of 52 reports were death-coded (9.6% of named reports, not a population mortality rate). Nearest volume peer: Decreased intra-ocular pressure (±0 reports). Lead species Dog (42). Lead co-reported drug Milbemycin Oxime + Spinosad (13).
Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Hypersensitivity to pain, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (52 here).
Similar death-coded share
Nearest other reactions by death-coded share (9.6% here), distinct from the volume row.
What to do with this reaction
- Compare Hypersensitivity to pain's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →