Reaction profile

The FDA adverse-event record for injection site haemorrhage

45 FDA adverse-event reports reference injection site haemorrhage (VeDDRA 82). See the species, breeds, and drugs most associated with it below.

45
reports citing this reaction
26.7%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
45
Total Reports
12
Deaths
26.7%
Death Rate

Species Most Affected

Dog 26
Human 8
Cattle 5
Horse 3
Cat 1
Other Birds 1
Chicken 1

Breeds Most Affected

Unknown 9
Mixed (Cattle) 2
Boxer (German Boxer) 2
Poodle - Toy 2
Retriever - Labrador 1
Hanovarian 1
Collie - Smooth-haired 1
Brangus 1
Lusitano 1
Shepherd Dog - Australian 1

Associated Drugs

Moxidectin 6
Polysulfated Glycosaminoglycan 5
Tigilanol Tiglate 5
Maropitant Citrate 4
Diphenhydramine 4
Ceftiofur Crystalline Free Acid 3
Prednisone 3
Butorphanol Tartrate 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 2
Rabies Virus, 2
Carprofen 2
Epinephrine 2
Atipamezole Hydrochloride 2
Famotidine 2
Dexmedetomidine Hydrochloride 2
Bedinvetmab 2
Gabapentin 2
Flunixin Meglumine + Oxytetracycline 1
Anesthetic 1
Ivermectin 1% Injection 1

Injection site haemorrhage Reaction Insights

45 reports name Injection site haemorrhage; 12 recorded a death outcome (26.7% of reported events, not a population-level mortality rate). VeDDRA code: 82.

By species: Dog (26 reports), Human (8 reports), Cattle (5 reports). By breed: Unknown (9), Mixed (Cattle) (2), Boxer (German Boxer) (2).

Most co-reported drugs: Moxidectin (6 reports), Polysulfated Glycosaminoglycan (5 reports), Tigilanol Tiglate (5 reports), Maropitant Citrate (4 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.