Reaction profile

The FDA adverse-event record for destructive behaviour

80 FDA adverse-event reports reference destructive behaviour (VeDDRA 2388). See the species, breeds, and drugs most associated with it below.

80
reports citing this reaction
10.0%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
80
Total Reports
8
Deaths
10.0%
Death Rate

Species Most Affected

Dog 66
Cat 7
Horse 5
Cattle 2

Breeds Most Affected

Retriever - Labrador 8
Dog (unknown) 7
Domestic Shorthair 5
Shepherd Dog - Australian 5
Crossbred Canine/dog 4
Quarter Horse 3
Poodle (unspecified) 3
Beagle 3
Pit Bull 3
Poodle - Toy 2

Associated Drugs

Oclacitinib Maleate 8
Imepitoin 8
Afoxolaner 7
Trilostane 6
Maropitant Citrate 5
Fluralaner Chew Tablets 5
Pergolide Mesylate 4
Carprofen 4
Frunevetmab 4
Bedinvetmab 4
Sarolaner 3
Milbemycin Oxime 3
Metronidazole 3
Ivermectin + Pyrantel As Pamoate Salt 3
Praziquantel 2
Milbemycin Oxime + Spinosad 2
Selamectin 2
Imidacloprid + Moxidectin 2
Febantel + Praziquantel + Pyrantel Pamoate 2
Buprenorphine 2

Destructive behaviour Reaction Insights

80 reports name Destructive behaviour; 8 recorded a death outcome (10.0% of reported events, not a population-level mortality rate). VeDDRA code: 2388.

By species: Dog (66 reports), Cat (7 reports), Horse (5 reports). By breed: Retriever - Labrador (8), Dog (unknown) (7), Domestic Shorthair (5).

Most co-reported drugs: Oclacitinib Maleate (8 reports), Imepitoin (8 reports), Afoxolaner (7 reports), Trilostane (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.