Reaction profile

The FDA adverse-event record for hepatic lipidosis (steatosis)

56 FDA adverse-event reports reference hepatic lipidosis (steatosis) (VeDDRA 2321). See the species, breeds, and drugs most associated with it below.

56
reports citing this reaction
66.1%
death-coded share
Cat
most-affected species
Bexagliflozin
most-associated drug
Verify with FDA CVM →
56
Total Reports
37
Deaths
66.1%
Death Rate

Species Most Affected

Cat 44
Dog 6
Cattle 2
Hedgehog 1
Horse 1
Mouse 1
Monkey 1

Breeds Most Affected

Domestic Shorthair 28
Domestic Longhair 3
Domestic Mediumhair 3
Cat (unknown) 3
Scottish Fold Shorthair 2
Turkish Angora 2
Crossbred Canine/dog 1
Jersey 1
Retriever - Golden 1
Lhasa Apso 1

Associated Drugs

Bexagliflozin 13
Velagliflozin Proline Monohydrate 10
Maropitant Citrate 9
Insulin 6
Buprenorphine 5
Maropitant 5
Ondansetron 5
Famotidine 5
Mirtazapine 5
Fluid Therapy 5
Cefovecin Sodium 5
Frunevetmab 5
Cyclosporine 4
Pantoprazole 4
Capromorelin Tartrate 4
Selamectin 4
Cefovecin 4
Dextrose 4
Capromorelin 3
Prescription Diet 3

Hepatic lipidosis (steatosis) Reaction Insights

56 reports name Hepatic lipidosis (steatosis); 37 recorded a death outcome (66.1% of reported events, not a population-level mortality rate). VeDDRA code: 2321.

By species: Cat (44 reports), Dog (6 reports), Cattle (2 reports). By breed: Domestic Shorthair (28), Domestic Longhair (3), Domestic Mediumhair (3).

Most co-reported drugs: Bexagliflozin (13 reports), Velagliflozin Proline Monohydrate (10 reports), Maropitant Citrate (9 reports), Insulin (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.