Reaction profile

The FDA adverse-event record for nervous system neoplasm

110 FDA adverse-event reports reference nervous system neoplasm (VeDDRA 669). See the species, breeds, and drugs most associated with it below.

110
reports citing this reaction
61.8%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
110
Total Reports
68
Deaths
61.8%
Death Rate

Species Most Affected

Dog 100
Cat 10

Breeds Most Affected

Boxer (German Boxer) 12
Collie - Border 8
Crossbred Canine/dog 8
Retriever - Labrador 7
Dog (unknown) 7
Pit Bull 6
Bulldog - French 4
Shepherd Dog - Australian 4
Retriever - Golden 4
Domestic (unspecified) 3

Associated Drugs

Milbemycin Oxime + Spinosad 17
Trilostane 12
Spinosad 9
Fluralaner Chew Tablets 8
Carprofen 6
Afoxolaner 6
Fluralaner 13.64% 12-Week Chew 6
Milbemycin Oxime 4
Gabapentin 4
Oclacitinib Maleate 4
Bedinvetmab 4
Cefovecin Sodium 3
Moxidectin 3
Pradofloxacin 3
Cyclosporine A 3
Ivermectin + Pyrantel As Pamoate Salt 3
Clotrimazole, Gentamicin Sulfate, Mometasone Furoate Monohydrate 2
Cyclosporine 2
Bordetella Vaccine 2
Anesthetic 2

Nervous system neoplasm Reaction Insights

110 reports name Nervous system neoplasm; 68 recorded a death outcome (61.8% of reported events, not a population-level mortality rate). VeDDRA code: 669.

By species: Dog (100 reports), Cat (10 reports). By breed: Boxer (German Boxer) (12), Collie - Border (8), Crossbred Canine/dog (8).

Most co-reported drugs: Milbemycin Oxime + Spinosad (17 reports), Trilostane (12 reports), Spinosad (9 reports), Fluralaner Chew Tablets (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.