Reaction profile

The FDA adverse-event record for nervous system neoplasm

111 FDA adverse-event reports reference nervous system neoplasm (VeDDRA 669). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1342 of 2,481
by report volume (all reactions)
111
reports citing this reaction
62.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Nervous system neoplasm has 111 reports now versus 111 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Nervous system neoplasm changes

FDA AER · VeDDRA plate

Code 669 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 111 reports
  • DEATH-HOT 62.2%
  • MID-PACK #1342/2481
  • PHOTO-FINISH Asthma
  • SPECIES-DOG Dog · 101
  • DRUG-LEAD Milbemycin Oxime… · 17
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Asthma (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Nervous system neoplasm

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Asthma · near111Counterfeit product · near111Elevated haemoglobin · near111Foreign body, medical… · near111Nervous system neopla… · thi…111Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Nervous system neoplasm

Nervous system neoplasm: high death-coded share in the FDA AER plate

Signature read: Nervous system neoplasm's 62.2% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 69 of 111 reports (62.2% of named reports). Nearest volume peer: Asthma (±0 reports). Lead species Dog (101). Lead co-reported drug Milbemycin Oxime + Spinosad (17).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 101
Cat 10

Breeds Most Affected

Boxer (German Boxer) 12
Collie - Border 8
Crossbred Canine/dog 8
Retriever - Labrador 7
Dog (unknown) 7
Pit Bull 6
Bulldog - French 4
Shepherd Dog - Australian 4
Retriever - Golden 4
Domestic (unspecified) 3

Associated Drugs

Milbemycin Oxime + Spinosad 17
Trilostane 12
Spinosad 9
Fluralaner Chew Tablets 8
Carprofen 6
Afoxolaner 6
Fluralaner 13.64% 12-Week Chew 6
Gabapentin 5
Bedinvetmab 5
Milbemycin Oxime 4
Oclacitinib Maleate 4
Cefovecin Sodium 3
Moxidectin 3
Pradofloxacin 3
Cyclosporine A 3
Ivermectin + Pyrantel As Pamoate Salt 3
Clotrimazole, Gentamicin Sulfate, Mometasone Furoate Monohydrate 2
Cyclosporine 2
Bordetella Vaccine 2
Anesthetic 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Nervous system neoplasm, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (111 here).

Similar death-coded share

Nearest other reactions by death-coded share (62.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Nervous system neoplasm (#1342 of 2,481 by report volume); death-coded 62.2%. PlainBreed reaction plate · death-coded share stamp 62.2% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →