Status epilepticus

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VeDDRA Code: 2473

64 adverse event reports referencing this reaction

64
Total Reports
39
Deaths
6090.0%
Death Rate

Species Most Affected

Dog 60
Cat 4

Breeds Most Affected

Chihuahua 5
Retriever - Labrador 5
Terrier (unspecified) 4
Boxer (German Boxer) 3
Retriever - Golden 3
Dog (unknown) 3
Crossbred Canine/dog 3
Collie - Border 3
Bulldog - French 2
Maltese 2

Associated Drugs

Fluralaner 13.64% 12-Week Chew 10
Fluralaner Chew Tablets 8
Pyrantel Pamoate;Sarolaner 8
Phenobarbital 6
Ivermectin + Pyrantel As Pamoate Salt 5
Bedinvetmab 5
Fluralaner 4
Diazepam 3
Levetiracetam 3
Zonisamide 3
Potassium Bromide 3
Afoxolaner 3
Sarolaner 2
Oclacitinib Maleate 2
Maropitant Citrate 2
Nitenpyram 2
Gabapentin 2
Lotilaner 2
Milbemycin Oxime + Praziquantel 2
Milbemycin Oxime 2

Data Summary

Metric Value
Total reports referencing reaction 64
Reports with fatal outcome 39
Case-fatality rate (reported events) 6090.0%
Species observed 2
Breeds observed 20
Drugs associated with reaction 20

Source: FDA Center for Veterinary Medicine — Adverse Event Reporting (CVM AER); reaction term coded under VeDDRA 2473.

Status epilepticus Reaction Insights

The FDA Center for Veterinary Medicine database currently lists 64 adverse event reports that reference Status epilepticus as a reaction term, including 39 reports with a death outcome — a 6090.0% case-fatality figure calculated across only those events where this reaction was coded. The reaction is indexed in the openFDA system under VeDDRA code 2473, the standardized veterinary dictionary used to normalize clinical signs across submitters. Because reports are voluntary and often describe multiple concurrent signs per animal, the volume here reflects reporting intensity rather than true incidence in the broader pet population.

Status epilepticus appears most frequently in reports for Dog (60 reports), Cat (4 reports) — with Dog dominating at 60 entries. Within those species, the breeds most often named alongside this reaction are Chihuahua (5), Retriever - Labrador (5), Terrier (unspecified) (4). These distributions are influenced both by underlying breed popularity and by how veterinarians and owners code a given clinical sign, so they should be interpreted as a reporting fingerprint rather than a pure susceptibility ranking.

The drugs most commonly co-reported with Status epilepticus are Fluralaner 13.64% 12-Week Chew (10 reports), Fluralaner Chew Tablets (8 reports), Pyrantel Pamoate;Sarolaner (8 reports), Phenobarbital (6 reports), with Fluralaner 13.64% 12-Week Chew appearing alongside this reaction in 10 submissions. Co-reporting does not establish that any specific product caused the reaction — FDA CVM data captures temporal association only. The value of these aggregates is in flagging which therapeutic classes appear repeatedly alongside a given clinical sign, so owners and veterinarians can ask targeted questions about medications currently in use.

Source: FDA Center for Veterinary Medicine — Adverse Event Reports FDA Center for Veterinary Medicine — Adverse Event Reports Data reflects voluntary submissions and may not represent actual incidence rates

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial