Reaction profile

The FDA adverse-event record for circulatory disorder nos

63 FDA adverse-event reports reference circulatory disorder nos (VeDDRA 2161). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1625 of 2,481
by report volume (all reactions)
63
reports citing this reaction
46.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Circulatory disorder NOS has 63 reports now versus 63 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Circulatory disorder NOS changes

FDA AER · VeDDRA plate

Code 2161 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 63 reports
  • DEATH-HOT 46.0%
  • MID-PACK #1625/2481
  • PHOTO-FINISH Application site sero…
  • SPECIES-DOG Dog · 49
  • DRUG-LEAD Moxidectin · 10
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Application site serosanguinous discharge (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

Report-volume neighbourhood around Circulatory disorder NOS

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Application site sero… · near63Circulatory disorder… · this…63DEATH-SLAUGHTERED · near63Hepatic lipidosis (st… · near63Monoparesis (paralysi… · near63Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Circulatory disorder NOS

Circulatory disorder NOS: high death-coded share in the FDA AER plate

Signature read: Circulatory disorder NOS's 46.0% death-coded share is among the highest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is upper-third: 29 of 63 reports (46.0% of named reports). Nearest volume peer: Application site serosanguinous discharge (±0 reports). Lead species Dog (49). Lead co-reported drug Moxidectin (10).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 49
Cat 10
Horse 2
Pig 1
Chicken 1

Breeds Most Affected

Domestic Shorthair 5
Siamese 4
Boxer (German Boxer) 4
Shepherd Dog - German 3
Dog (unknown) 3
Dachshund (unspecified) 3
Schnauzer - Miniature 2
Retriever - Golden 2
Maltese 2
Chihuahua 2

Associated Drugs

Moxidectin 10
Carprofen 8
Milbemycin Oxime + Spinosad 6
Spinosad 4
Oclacitinib Maleate 4
Isoflurane 4
Maropitant Citrate 4
Melarsomine Dihydrochloride 4
Acepromazine 3
Afoxolaner 68 Mg Chewable Tablets 3
Trilostane 3
Rabies Virus, 3
Gabapentin 3
Fish Oil 2
Famotidine 2
Prednisone 2
Afoxolaner 2
Buprenorphine 2
Dexamethasone 2
Amlodipine 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Circulatory disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (46.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Circulatory disorder NOS (#1625 of 2,481 by report volume); death-coded 46.0%. PlainBreed reaction plate · death-coded share stamp 46.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →