Reaction profile

The FDA adverse-event record for application site serosanguinous discharge

62 FDA adverse-event reports reference application site serosanguinous discharge (VeDDRA 33). See the species, breeds, and drugs most associated with it below.

62
reports citing this reaction
4.8%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
62
Total Reports
3
Deaths
4.8%
Death Rate

Species Most Affected

Cat 31
Dog 30
Horse 1

Breeds Most Affected

Domestic Shorthair 22
Crossbred Canine/dog 5
Domestic Longhair 4
Retriever - Labrador 3
Domestic Mediumhair 2
Retriever - Golden 2
Shepherd Dog - German 2
Shepherd Dog - Australian 1
Mixed (Dog) 1
Hound - Basset 1

Associated Drugs

Selamectin 14
Imidacloprid + Moxidectin 9
Bupivacaine Lipsome Injectable Suspension 9
Hydromorphone 9
Isoflurane 9
Acepromazine 8
Diazepam 8
Propfol 8
Oxygen 8
Morphine 8
Cefazolin 8
Hydromorphone/Lidocaine/Ketamine Cri 8
Tramadol 8
Carprofen 8
Cefpodoxime 8
Flumethrin-Imidacloprid 7
Selamectin;Sarolaner 7
Enrofloxacin 4
Prednisone 4
Emodepside + Praziquantel 3

Application site serosanguinous discharge Reaction Insights

62 reports name Application site serosanguinous discharge; 3 recorded a death outcome (4.8% of reported events, not a population-level mortality rate). VeDDRA code: 33.

By species: Cat (31 reports), Dog (30 reports), Horse (1 reports). By breed: Domestic Shorthair (22), Crossbred Canine/dog (5), Domestic Longhair (4).

Most co-reported drugs: Selamectin (14 reports), Imidacloprid + Moxidectin (9 reports), Bupivacaine Lipsome Injectable Suspension (9 reports), Hydromorphone (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.