Reaction profile

The FDA adverse-event record for allergy nos

1,155 FDA reports name allergy nos, a high-volume reaction in the CVM extract (VeDDRA 1307). Plate stamps and neighbourhood peers follow.

#347 of 2,481
by report volume (all reactions)
1,155
reports citing this reaction
2.2%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Allergy NOS has 1,155 reports now versus 1,134 in that prior snapshot: 21 more (1.9%).

Report change
+21
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Allergy NOS changes

FDA AER · VeDDRA plate

Code 1307 VOL-MID

VOL-MID · DEATH-LOW · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,155 reports
  • DEATH-LOW 2.2%
  • UPPER-Q #347/2481
  • PHOTO-FINISH Head tilt - neurologi…
  • SPECIES-DOG Dog · 1,097
  • DRUG-LEAD Milbemycin Oxime… · 562
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Head tilt - neurological disorder (see also Head tilt - ear disorder) (±2 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Allergy NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Febrile · near1164Allergy NOS · this reaction1155Head tilt - neurologi… · near1153Head shake - behaviou… · near1152Excessive thirst · near1144Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Allergy NOS

Allergy NOS: low death-coded share in the FDA AER plate

Signature read: 1,155 reports place Allergy NOS in the upper third of FDA AER volume (#347 of 2,481). Report volume is upper-third scale: 1,155 named reports in the openFDA extract. Death-coded share is lower-third: 25 of 1,155 reports (2.2% of named reports). Nearest volume peer: Head tilt - neurological disorder (see also Head tilt - ear disorder) (±2 reports). Lead species Dog (1,097). Lead co-reported drug Milbemycin Oxime + Spinosad (562).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,097
Cat 42
Human 9
Cattle 3
Horse 2
Donkey 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 129
Dog (unknown) 67
Crossbred Canine/dog 65
Pit Bull 56
Shepherd Dog - German 45
Retriever - Golden 45
Chihuahua 42
Shih Tzu 41
Terrier - Yorkshire 41
Boxer (German Boxer) 33

Associated Drugs

Milbemycin Oxime + Spinosad 562
Milbemycin Oxime + Praziquantel 198
Oclacitinib Maleate 99
Spinosad 91
Lotilaner 49
Afoxolaner 44
Fluralaner 13.64% 12-Week Chew 43
Moxidectin 36
Ivermectin + Pyrantel As Pamoate Salt 35
Milbemycin Oxime 33
Imidacloprid + Moxidectin 32
Prednisone 29
Cyclosporine 28
Trilostane 26
Diphenhydramine 24
Fluralaner 23
Gabapentin 21
Carprofen 19
Grapiprant 18
Sarolaner 18

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Allergy NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (2.2% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Allergy NOS (#347 of 2,481 by report volume); death-coded 2.2%. PlainBreed reaction plate · report volume stamp 1,155 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →