Reaction profile

The FDA adverse-event record for allergy nos

1,111 FDA adverse-event reports reference allergy nos (VeDDRA 1307). See the species, breeds, and drugs most associated with it below.

1,111
reports citing this reaction
2.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,111
Total Reports
25
Deaths
2.3%
Death Rate

Species Most Affected

Dog 1,059
Cat 37
Human 8
Cattle 3
Horse 2
Donkey 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 124
Dog (unknown) 66
Crossbred Canine/dog 63
Pit Bull 56
Shepherd Dog - German 45
Retriever - Golden 42
Chihuahua 41
Terrier - Yorkshire 39
Shih Tzu 38
Boxer (German Boxer) 30

Associated Drugs

Milbemycin Oxime + Spinosad 562
Milbemycin Oxime + Praziquantel 187
Spinosad 90
Oclacitinib Maleate 84
Afoxolaner 43
Fluralaner 13.64% 12-Week Chew 40
Lotilaner 39
Moxidectin 36
Milbemycin Oxime 33
Ivermectin + Pyrantel As Pamoate Salt 33
Imidacloprid + Moxidectin 30
Prednisone 28
Cyclosporine 26
Trilostane 26
Diphenhydramine 23
Fluralaner 23
Gabapentin 21
Sarolaner 18
Maropitant Citrate 17
Unspecified 17

Allergy NOS Reaction Insights

1,111 reports name Allergy NOS; 25 recorded a death outcome (2.3% of reported events, not a population-level mortality rate). VeDDRA code: 1307.

By species: Dog (1,059 reports), Cat (37 reports), Human (8 reports). By breed: Retriever - Labrador (124), Dog (unknown) (66), Crossbred Canine/dog (63).

Most co-reported drugs: Milbemycin Oxime + Spinosad (562 reports), Milbemycin Oxime + Praziquantel (187 reports), Spinosad (90 reports), Oclacitinib Maleate (84 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.