Reaction profile

The FDA adverse-event record for cardiac enlargement

1,100 FDA adverse-event reports reference cardiac enlargement (VeDDRA 204). See the species, breeds, and drugs most associated with it below.

1,100
reports citing this reaction
39.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,100
Total Reports
432
Deaths
39.3%
Death Rate

Species Most Affected

Dog 868
Cat 195
Cattle 26
Other Birds 3
Pig 3
Sheep 2
Other Canids 1
Human 1
Horse 1

Breeds Most Affected

Domestic Shorthair 88
Chihuahua 84
Retriever - Labrador 63
Terrier - Yorkshire 53
Crossbred Canine/dog 48
Dachshund (unspecified) 35
Domestic (unspecified) 34
Shih Tzu 34
Maltese 30
Beagle 27

Associated Drugs

Milbemycin Oxime + Spinosad 166
Bedinvetmab 76
Maropitant Citrate 73
Trilostane 63
Pimobendan 59
Furosemide 53
Moxidectin 52
Cefovecin 52
Spinosad 50
Prednisone 49
Oclacitinib Maleate 49
Gabapentin 43
Ivermectin + Pyrantel As Pamoate Salt 42
Carprofen 40
Afoxolaner 38
Selamectin 36
Doxycycline 34
Milbemycin Oxime + Praziquantel 33
Fluralaner Chew Tablets 30
Imidacloprid + Moxidectin 28

Cardiac enlargement Reaction Insights

1,100 reports name Cardiac enlargement; 432 recorded a death outcome (39.3% of reported events, not a population-level mortality rate). VeDDRA code: 204.

By species: Dog (868 reports), Cat (195 reports), Cattle (26 reports). By breed: Domestic Shorthair (88), Chihuahua (84), Retriever - Labrador (63).

Most co-reported drugs: Milbemycin Oxime + Spinosad (166 reports), Bedinvetmab (76 reports), Maropitant Citrate (73 reports), Trilostane (63 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.