Reaction profile

The FDA adverse-event record for excessive thirst

1,144 FDA reports name excessive thirst, a high-volume reaction in the CVM extract (VeDDRA 544). Plate stamps and neighbourhood peers follow.

#350 of 2,481
by report volume (all reactions)
1,144
reports citing this reaction
14.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Excessive thirst has 1,144 reports now versus 1,117 in that prior snapshot: 27 more (2.4%).

Report change
+27
Death-coded reports
+5
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Excessive thirst changes

FDA AER · VeDDRA plate

Code 544 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,144 reports
  • DEATH-ELEV 14.7%
  • UPPER-Q #350/2481
  • PHOTO-FINISH Cardiac enlargement
  • SPECIES-DOG Dog · 1,012
  • DRUG-LEAD Bedinvetmab · 188
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Cardiac enlargement (±4 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Excessive thirst

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Head shake - behaviou… · near1152Excessive thirst · this reac…1144Cardiac enlargement · near1140Hypothyroidism · near1137Regurgitation · near1136Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Excessive thirst

What the FDA AER plate says about Excessive thirst

Signature read: 168 death-coded reports is a heavy tail count for Excessive thirst in the CVM extract. Report volume is upper-third scale: 1,144 named reports in the openFDA extract. 168 of 1,144 reports were death-coded (14.7% of named reports, not a population mortality rate). Nearest volume peer: Cardiac enlargement (±4 reports). Lead species Dog (1,012). Lead co-reported drug Bedinvetmab (188).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,012
Cat 122
Human 5
Horse 3
Pig 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 113
Domestic Shorthair 70
Shepherd Dog - German 68
Crossbred Canine/dog 63
Retriever - Golden 50
Dog (unknown) 43
Shih Tzu 31
Boxer (German Boxer) 29
Chihuahua 24
Terrier - Bull - American Pit 23

Associated Drugs

Bedinvetmab 188
Milbemycin Oxime + Spinosad 99
Carprofen 75
Afoxolaner 69
Spinosad 68
Pyrantel Pamoate;Sarolaner 65
Fluralaner Chew Tablets 62
Gabapentin 60
Prednisone 45
Oclacitinib Maleate 42
Ivermectin + Pyrantel As Pamoate Salt 38
Maropitant Citrate 37
Milbemycin Oxime + Praziquantel 32
Grapiprant 30
Fluralaner 13.64% 12-Week Chew 29
Pimobendan 21
Tramadol 21
Meloxicam 21
Lotilaner 21
Nitenpyram 19

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Excessive thirst, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,144 here).

Similar death-coded share

Nearest other reactions by death-coded share (14.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Excessive thirst (#350 of 2,481 by report volume); death-coded 14.7%. PlainBreed reaction plate · death-coded report count stamp 168 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →