Reaction profile

The FDA adverse-event record for excessive thirst

1,086 FDA adverse-event reports reference excessive thirst (VeDDRA 544). See the species, breeds, and drugs most associated with it below.

1,086
reports citing this reaction
14.3%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
1,086
Total Reports
155
Deaths
14.3%
Death Rate

Species Most Affected

Dog 965
Cat 111
Human 5
Horse 3
Pig 1
Rabbit 1

Breeds Most Affected

Retriever - Labrador 111
Shepherd Dog - German 68
Domestic Shorthair 64
Crossbred Canine/dog 61
Retriever - Golden 49
Dog (unknown) 43
Shih Tzu 30
Boxer (German Boxer) 26
Chihuahua 23
Shepherd Dog - Australian 22

Associated Drugs

Bedinvetmab 170
Milbemycin Oxime + Spinosad 99
Carprofen 69
Spinosad 68
Afoxolaner 67
Pyrantel Pamoate;Sarolaner 63
Fluralaner Chew Tablets 62
Gabapentin 55
Prednisone 43
Oclacitinib Maleate 39
Ivermectin + Pyrantel As Pamoate Salt 38
Milbemycin Oxime + Praziquantel 29
Fluralaner 13.64% 12-Week Chew 29
Maropitant Citrate 28
Grapiprant 28
Tramadol 21
Pimobendan 19
Lotilaner 19
Phenylpropropanolamine Hcl 19
Meloxicam 18

Excessive thirst Reaction Insights

1,086 reports name Excessive thirst; 155 recorded a death outcome (14.3% of reported events, not a population-level mortality rate). VeDDRA code: 544.

By species: Dog (965 reports), Cat (111 reports), Human (5 reports). By breed: Retriever - Labrador (111), Shepherd Dog - German (68), Domestic Shorthair (64).

Most co-reported drugs: Bedinvetmab (170 reports), Milbemycin Oxime + Spinosad (99 reports), Carprofen (69 reports), Spinosad (68 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.