Reaction profile

The FDA adverse-event record for pyrexia

608 FDA adverse-event reports reference pyrexia (VeDDRA 1031). See the species, breeds, and drugs most associated with it below.

608
reports citing this reaction
15.0%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
608
Total Reports
91
Deaths
15.0%
Death Rate

Species Most Affected

Dog 357
Cat 211
Horse 23
Cattle 12
Human 4
Goat 1

Breeds Most Affected

Domestic Shorthair 147
Retriever - Labrador 45
Domestic Longhair 20
Crossbred Canine/dog 19
Shepherd Dog - German 16
Retriever - Golden 12
Terrier - Yorkshire 11
Domestic Mediumhair 10
Collie - Border 10
Dog (unknown) 10

Associated Drugs

Imidacloprid + Moxidectin 114
Emodepside + Praziquantel 52
Enrofloxacin 42
Buprenorphine 36
Milbemycin Oxime + Spinosad 34
Afoxolaner 32
Robenacoxib 30
Maropitant Citrate 28
Moxidectin 23
Meloxicam 22
Rabies Vaccine 19
Trilostane 18
Cefovecin Sodium 18
Prednisone 17
Carprofen 17
Fluids 17
Doxycycline 15
Diphenhydramine 14
Ivermectin + Pyrantel As Pamoate Salt 14
Gabapentin 14

Pyrexia Reaction Insights

608 reports name Pyrexia; 91 recorded a death outcome (15.0% of reported events, not a population-level mortality rate). VeDDRA code: 1031.

By species: Dog (357 reports), Cat (211 reports), Horse (23 reports). By breed: Domestic Shorthair (147), Retriever - Labrador (45), Domestic Longhair (20).

Most co-reported drugs: Imidacloprid + Moxidectin (114 reports), Emodepside + Praziquantel (52 reports), Enrofloxacin (42 reports), Buprenorphine (36 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.