Reaction profile

The FDA adverse-event record for circulatory collapse (see also 'neurological' and 'systemic disorders')

445 FDA adverse-event reports reference circulatory collapse (see also 'neurological' and 'systemic disorders') (VeDDRA 223). See the species, breeds, and drugs most associated with it below.

445
reports citing this reaction
25.4%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
445
Total Reports
113
Deaths
25.4%
Death Rate

Species Most Affected

Dog 395
Cat 39
Horse 5
Cattle 4
Other Canids 1
Human 1

Breeds Most Affected

Boxer (German Boxer) 40
Terrier - Bull - American Pit 33
Retriever - Labrador 27
Domestic Shorthair 20
Shepherd Dog - German 16
Chihuahua 16
Terrier - Yorkshire 16
Shih Tzu 15
Pug 14
Retriever - Golden 13

Associated Drugs

Moxidectin 223
Maropitant Citrate 46
Diphenhydramine Hcl 39
Cefovecin 35
Rabies Virus, Kv 33
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76; Canine Distemper Virus, St 30
Dexamethasone 30
Rabies Virus, 29
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 26
Bordetella Bronchiseptica, Strain 78-9159, Kb 18
Melarsomine Dihydrochloride 18
Carprofen 17
Epinephrine 16
Leptospira Canicola L-15 Strain C-51; Leptospira Grippotyphosa 1550 Lot 10005 St 16
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 16
Melarsomine Dihydrochloride Injection 14
Pyrantel Pamoate 13
Famotidine 13
Pimobendan 13
Selamectin 10

Circulatory collapse (see also 'Neurological' and 'Systemic disorders') Reaction Insights

445 reports name Circulatory collapse (see also 'Neurological' and 'Systemic disorders'); 113 recorded a death outcome (25.4% of reported events, not a population-level mortality rate). VeDDRA code: 223.

By species: Dog (395 reports), Cat (39 reports), Horse (5 reports). By breed: Boxer (German Boxer) (40), Terrier - Bull - American Pit (33), Retriever - Labrador (27).

Most co-reported drugs: Moxidectin (223 reports), Maropitant Citrate (46 reports), Diphenhydramine Hcl (39 reports), Cefovecin (35 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.