Reaction profile

The FDA adverse-event record for coma

339 FDA adverse-event reports reference coma (VeDDRA 664). See the species, breeds, and drugs most associated with it below.

339
reports citing this reaction
64.0%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
339
Total Reports
217
Deaths
64.0%
Death Rate

Species Most Affected

Dog 224
Cat 98
Human 5
Horse 4
Cattle 2
Pig 1
Rabbit 1
Buffalo 1
Rat 1
Donkey 1

Breeds Most Affected

Domestic Shorthair 54
Crossbred Canine/dog 18
Shepherd Dog - Australian 14
Cat (unknown) 12
Terrier - Yorkshire 11
Retriever - Golden 11
Chihuahua 10
Siberian Husky 9
Unknown 8
Retriever - Labrador 8

Associated Drugs

Milbemycin Oxime + Spinosad 34
Maropitant Citrate 32
Cefovecin 24
Ivermectin 21
Isoflurane 19
Buprenorphine 16
Carprofen 16
Dexamethasone 13
Famotidine 12
Spinosad 12
Imidacloprid + Moxidectin 11
Afoxolaner 11
Trilostane 10
Ketamine 10
Diazepam 10
Moxidectin 9
Selamectin 9
Robenacoxib 9
Enrofloxacin 8
Butorphanol 8

Coma Reaction Insights

339 reports name Coma; 217 recorded a death outcome (64.0% of reported events, not a population-level mortality rate). VeDDRA code: 664.

By species: Dog (224 reports), Cat (98 reports), Human (5 reports). By breed: Domestic Shorthair (54), Crossbred Canine/dog (18), Shepherd Dog - Australian (14).

Most co-reported drugs: Milbemycin Oxime + Spinosad (34 reports), Maropitant Citrate (32 reports), Cefovecin (24 reports), Ivermectin (21 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.