Reaction profile

The FDA adverse-event record for coma

348 FDA reports name coma, a high-volume reaction in the CVM extract (VeDDRA 664). Plate stamps and neighbourhood peers follow.

#814 of 2,481
by report volume (all reactions)
348
reports citing this reaction
64.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Coma has 348 reports now versus 344 in that prior snapshot: 4 more (1.2%).

Report change
+4
Death-coded reports
+4
Death-coded share
+0.4 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Coma changes

FDA AER · VeDDRA plate

Code 664 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 348 reports
  • DEATH-HOT 64.7%
  • MID-PACK #814/2481
  • PHOTO-FINISH Injection site redden…
  • SPECIES-DOG Dog · 231
  • DRUG-LEAD Maropitant Citrate · 35
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Injection site reddening (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Coma

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Autoimmune disorder N… · near350Coma · this reaction348Injection site redden… · near347Miosis · near347Applicator, Abnormal · near346Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Coma

Coma: high death-coded share in the FDA AER plate

Signature read: Coma's 64.7% death-coded share is among the highest in the openFDA reaction corpus. Report volume is upper-third scale: 348 named reports in the openFDA extract. Death-coded share is upper-third: 225 of 348 reports (64.7% of named reports). Nearest volume peer: Injection site reddening (±1 reports). Lead species Dog (231). Lead co-reported drug Maropitant Citrate (35).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 231
Cat 100
Human 5
Horse 4
Cattle 2
Pig 1
Rabbit 1
Buffalo 1
Rat 1
Donkey 1

Breeds Most Affected

Domestic Shorthair 55
Crossbred Canine/dog 18
Shepherd Dog - Australian 14
Cat (unknown) 12
Terrier - Yorkshire 11
Retriever - Golden 11
Chihuahua 10
Siberian Husky 10
Unknown 8
Retriever - Labrador 8

Associated Drugs

Maropitant Citrate 35
Milbemycin Oxime + Spinosad 34
Cefovecin 24
Ivermectin 21
Isoflurane 19
Buprenorphine 17
Carprofen 16
Famotidine 14
Dexamethasone 14
Spinosad 12
Afoxolaner 12
Imidacloprid + Moxidectin 11
Moxidectin 10
Trilostane 10
Ketamine 10
Diazepam 10
Selamectin 9
Gabapentin 9
Robenacoxib 9
Pyrantel Pamoate;Sarolaner 9

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Coma, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (348 here).

Similar death-coded share

Nearest other reactions by death-coded share (64.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Coma (#814 of 2,481 by report volume); death-coded 64.7%. PlainBreed reaction plate · death-coded share stamp 64.7% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →