Reaction profile

The FDA adverse-event record for eyelid oedema

442 FDA adverse-event reports reference eyelid oedema (VeDDRA 1100). See the species, breeds, and drugs most associated with it below.

442
reports citing this reaction
3.8%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
442
Total Reports
17
Deaths
3.8%
Death Rate

Species Most Affected

Dog 345
Cat 37
Cattle 27
Horse 19
Human 14

Breeds Most Affected

Crossbred Canine/dog 41
Retriever - Labrador 27
Boxer (German Boxer) 25
Chihuahua 21
Retriever - Golden 17
Domestic Shorthair 16
Unknown 15
Holstein-Friesian also known as Holstein 13
Domestic (unspecified) 10
Terrier - Yorkshire 10

Associated Drugs

Moxidectin 53
Spinosad 29
Milbemycin Oxime + Spinosad 28
Selamectin 15
Spinosad, Milbemycin 14
Maropitant 10
Carprofen 10
Oclacitinib Maleate 10
Ivermectin, Pyrantel 9
Prednisone 9
Maropitant Citrate 9
Ivermectin 8
Cyclosporine 8
Imidacloprid + Moxidectin 8
Afoxolaner 8
Dexmedetomidine Hydrochloride 7
Cefovecin Sodium 7
Fluralaner Chew Tablets 7
Meloxicam 6
Melarsomine Dihydrochloride 6

Eyelid oedema Reaction Insights

442 reports name Eyelid oedema; 17 recorded a death outcome (3.8% of reported events, not a population-level mortality rate). VeDDRA code: 1100.

By species: Dog (345 reports), Cat (37 reports), Cattle (27 reports). By breed: Crossbred Canine/dog (41), Retriever - Labrador (27), Boxer (German Boxer) (25).

Most co-reported drugs: Moxidectin (53 reports), Spinosad (29 reports), Milbemycin Oxime + Spinosad (28 reports), Selamectin (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.