Reaction profile

The FDA adverse-event record for low creatinine

384 FDA adverse-event reports reference low creatinine (VeDDRA 2701). See the species, breeds, and drugs most associated with it below.

384
reports citing this reaction
24.5%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
384
Total Reports
94
Deaths
24.5%
Death Rate

Species Most Affected

Dog 252
Cat 128
Cattle 2
Horse 2

Breeds Most Affected

Domestic Shorthair 87
Chihuahua 26
Terrier - Yorkshire 25
Crossbred Canine/dog 20
Shih Tzu 14
Retriever - Labrador 13
Maltese 12
Dachshund (unspecified) 11
Domestic Longhair 10
Domestic Mediumhair 8

Associated Drugs

Trilostane 52
Maropitant Citrate 39
Afoxolaner 22
Milbemycin Oxime + Spinosad 20
Buprenorphine 18
Bexagliflozin 17
Eprinomectin + Esafoxolaner + Praziquantel 17
Cefovecin 16
Metronidazole 16
Selamectin 15
Fluid Therapy 15
Oclacitinib Maleate 14
Velagliflozin Proline Monohydrate 13
Meloxicam 12
Carprofen 12
Gabapentin 12
Enrofloxacin 11
Doxycycline 11
Robenacoxib 10
Cefovecin Sodium 10

Low creatinine Reaction Insights

384 reports name Low creatinine; 94 recorded a death outcome (24.5% of reported events, not a population-level mortality rate). VeDDRA code: 2701.

By species: Dog (252 reports), Cat (128 reports), Cattle (2 reports). By breed: Domestic Shorthair (87), Chihuahua (26), Terrier - Yorkshire (25).

Most co-reported drugs: Trilostane (52 reports), Maropitant Citrate (39 reports), Afoxolaner (22 reports), Milbemycin Oxime + Spinosad (20 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.