Reaction profile

The FDA adverse-event record for loss of bowel control

419 FDA adverse-event reports reference loss of bowel control (VeDDRA 1070). See the species, breeds, and drugs most associated with it below.

419
reports citing this reaction
25.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
419
Total Reports
105
Deaths
25.1%
Death Rate

Species Most Affected

Dog 377
Cat 38
Horse 3
Duck 1

Breeds Most Affected

Retriever - Labrador 45
Crossbred Canine/dog 34
Chihuahua 24
Domestic Shorthair 22
Shepherd Dog - German 19
Dog (unknown) 14
Boxer (German Boxer) 13
Retriever - Golden 13
Terrier - Yorkshire 9
Terrier - Bull - American Pit 8

Associated Drugs

Milbemycin Oxime + Spinosad 54
Afoxolaner 51
Bedinvetmab 44
Ivermectin + Pyrantel As Pamoate Salt 35
Moxidectin 29
Carprofen 22
Maropitant Citrate 21
Gabapentin 19
Pyrantel Pamoate;Sarolaner 17
Milbemycin Oxime + Praziquantel 16
Fluralaner 13.64% 12-Week Chew 16
Fluralaner Chew Tablets 15
Spinosad 12
Sarolaner 12
Melarsomine Dihydrochloride 10
Lotilaner 10
Trilostane 8
Selamectin 8
Tramadol 7
Grapiprant 7

Loss of bowel control Reaction Insights

419 reports name Loss of bowel control; 105 recorded a death outcome (25.1% of reported events, not a population-level mortality rate). VeDDRA code: 1070.

By species: Dog (377 reports), Cat (38 reports), Horse (3 reports). By breed: Retriever - Labrador (45), Crossbred Canine/dog (34), Chihuahua (24).

Most co-reported drugs: Milbemycin Oxime + Spinosad (54 reports), Afoxolaner (51 reports), Bedinvetmab (44 reports), Ivermectin + Pyrantel As Pamoate Salt (35 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.