Reaction profile

The FDA adverse-event record for pr-kidney(s), lesion(s)

448 FDA adverse-event reports reference pr-kidney(s), lesion(s) (VeDDRA 99627). See the species, breeds, and drugs most associated with it below.

448
reports citing this reaction
96.9%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
448
Total Reports
434
Deaths
96.9%
Death Rate

Species Most Affected

Dog 284
Cat 130
Cattle 25
Horse 5
Other Birds 2
Turtle 1
Mouse 1

Breeds Most Affected

Domestic (unspecified) 64
Retriever - Labrador 43
Domestic Shorthair 36
Crossbred Canine/dog 29
Retriever - Golden 16
Holstein-Friesian also known as Holstein 13
Boxer (German Boxer) 10
Shepherd Dog - German 9
Chihuahua 9
Cat (unknown) 8

Associated Drugs

Carprofen 65
Robenacoxib 31
Milbemycin Oxime + Spinosad 29
Meloxicam 26
Cefovecin 23
Maropitant Citrate 23
Cefovecin Sodium 22
Fluralaner Chew Tablets 22
Spinosad 21
Moxidectin 21
Oclacitinib Maleate 18
Afoxolaner 18
Maropitant 17
Deracoxib 14
Dexmedetomidine Hydrochloride 14
Enrofloxacin 13
Grapiprant 12
Dexamethasone 9
Famotidine 9
Buprenorphine 9

PR-KIDNEY(S), LESION(S) Reaction Insights

448 reports name PR-KIDNEY(S), LESION(S); 434 recorded a death outcome (96.9% of reported events, not a population-level mortality rate). VeDDRA code: 99627.

By species: Dog (284 reports), Cat (130 reports), Cattle (25 reports). By breed: Domestic (unspecified) (64), Retriever - Labrador (43), Domestic Shorthair (36).

Most co-reported drugs: Carprofen (65 reports), Robenacoxib (31 reports), Milbemycin Oxime + Spinosad (29 reports), Meloxicam (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.