Reaction profile

The FDA adverse-event record for blinking

230 FDA adverse-event reports reference blinking (VeDDRA 1101). See the species, breeds, and drugs most associated with it below.

230
reports citing this reaction
3.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
230
Total Reports
8
Deaths
3.5%
Death Rate

Species Most Affected

Dog 148
Cat 80
Human 1
Horse 1

Breeds Most Affected

Domestic Shorthair 38
Domestic Longhair 15
Retriever - Golden 14
Retriever - Labrador 12
Domestic Mediumhair 10
Crossbred Canine/dog 8
Spitz - German Pomeranian 7
Terrier (unspecified) 7
Cat (unknown) 7
Boxer (German Boxer) 6

Associated Drugs

Milbemycin Oxime + Spinosad 46
Imidacloprid + Moxidectin 20
Selamectin 17
Afoxolaner 14
Pyrantel Pamoate;Sarolaner 13
Sarolaner 12
Fluralaner 13.64% 12-Week Chew 10
Fluralaner Spot-On Solution 10
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 10
Maropitant Citrate 8
Buprenorphine 8
Selamectin;Sarolaner 7
Nitenpyram 6
Milbemycin Oxime + Praziquantel 6
Ivermectin + Pyrantel As Pamoate Salt 5
Oclacitinib Maleate 5
Fluralaner/Moxidectin Spot-On 5
Spinosad 4
Enrofloxacin 4
Grapiprant 4

Blinking Reaction Insights

230 reports name Blinking; 8 recorded a death outcome (3.5% of reported events, not a population-level mortality rate). VeDDRA code: 1101.

By species: Dog (148 reports), Cat (80 reports), Human (1 reports). By breed: Domestic Shorthair (38), Domestic Longhair (15), Retriever - Golden (14).

Most co-reported drugs: Milbemycin Oxime + Spinosad (46 reports), Imidacloprid + Moxidectin (20 reports), Selamectin (17 reports), Afoxolaner (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.