Reaction profile

The FDA adverse-event record for ear discharge

1,036 FDA adverse-event reports reference ear discharge (VeDDRA 349). See the species, breeds, and drugs most associated with it below.

1,036
reports citing this reaction
5.0%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
1,036
Total Reports
52
Deaths
5.0%
Death Rate

Species Most Affected

Dog 851
Cat 177
Pig 2
Cattle 2
Horse 2
Unknown 1
Other Cervids 1

Breeds Most Affected

Retriever - Labrador 118
Domestic Shorthair 111
Retriever - Golden 55
Crossbred Canine/dog 49
Shih Tzu 37
Dog (unknown) 34
Terrier - Yorkshire 27
Maltese 25
Pug 25
Shepherd Dog - German 25

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 180
Betamethasone + Florfenicol + Terbinafine 159
Milbemycin Oxime + Spinosad 83
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 63
Carprofen 54
Prednisone 49
Imidacloprid + Moxidectin 47
Maropitant Citrate 43
Oclacitinib Maleate 43
Ear Cleaner (Unknown) 39
Enrofloxacin 38
Miconazole + Polymyxin B + Prednisolone 36
Afoxolaner 36
Florfenicol + Mometasone Furoate + Terbinafine 36
Ear Cleaner 35
Gabapentin 33
Florfenicol, Terbinafine, Betamethasone Acetate 31
Genta/Momet/Clotrim Ear Oint 26
Ketoconazole 25
Spinosad 24

Ear discharge Reaction Insights

1,036 reports name Ear discharge; 52 recorded a death outcome (5.0% of reported events, not a population-level mortality rate). VeDDRA code: 349.

By species: Dog (851 reports), Cat (177 reports), Pig (2 reports). By breed: Retriever - Labrador (118), Domestic Shorthair (111), Retriever - Golden (55).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (180 reports), Betamethasone + Florfenicol + Terbinafine (159 reports), Milbemycin Oxime + Spinosad (83 reports), Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate (63 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.