Reaction profile

The FDA adverse-event record for distension of abdomen

1,754 FDA reports name distension of abdomen, a high-volume reaction in the CVM extract (VeDDRA 312). Plate stamps and neighbourhood peers follow.

#257 of 2,481
by report volume (all reactions)
1,754
reports citing this reaction
34.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Distension of abdomen has 1,754 reports now versus 1,727 in that prior snapshot: 27 more (1.6%).

Report change
+27
Death-coded reports
+8
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Distension of abdomen changes

FDA AER · VeDDRA plate

Code 312 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 1,754 reports
  • DEATH-HOT 34.7%
  • UPPER-Q #257/2481
  • PHOTO-FINISH Crying
  • SPECIES-DOG Dog · 1,546
  • DRUG-LEAD Trilostane · 335
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Crying (±3 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Distension of abdomen

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Neoplasia NOS · near1770Sneezing · near1770Distension of abdomen · this…1754Crying · near1751Uncomfortable · near1733Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Distension of abdomen

Distension of abdomen: high death-coded share in the FDA AER plate

Signature read: 608 death-coded reports is a heavy tail count for Distension of abdomen in the CVM extract. Report volume is upper-third scale: 1,754 named reports in the openFDA extract. Death-coded share is upper-third: 608 of 1,754 reports (34.7% of named reports). Nearest volume peer: Crying (±3 reports). Lead species Dog (1,546). Lead co-reported drug Trilostane (335).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 1,546
Cat 177
Horse 17
Cattle 7
Other Canids 1
Ferret 1
Chicken 1
Pig 1
Bison 1
Mouse 1

Breeds Most Affected

Retriever - Labrador 187
Crossbred Canine/dog 127
Chihuahua 90
Domestic Shorthair 89
Terrier - Yorkshire 71
Shih Tzu 45
Beagle 42
Maltese 41
Shepherd Dog - German 40
Retriever - Golden 39

Associated Drugs

Trilostane 335
Milbemycin Oxime + Spinosad 181
Carprofen 177
Maropitant Citrate 118
Oclacitinib Maleate 89
Deracoxib 82
Bedinvetmab 80
Gabapentin 64
Prednisone 60
Spinosad 56
Tramadol 52
Fluralaner Chew Tablets 49
Afoxolaner 48
Meloxicam 42
Moxidectin 41
Fluralaner 13.64% 12-Week Chew 41
Metronidazole 38
Ivermectin + Pyrantel As Pamoate Salt 38
Selamectin 37
Famotidine 36

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Distension of abdomen, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (1,754 here).

Similar death-coded share

Nearest other reactions by death-coded share (34.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Distension of abdomen (#257 of 2,481 by report volume); death-coded 34.7%. PlainBreed reaction plate · death-coded report count stamp 608 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →